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AuthorDanne, Thomasdc.contributor.author
AuthorSchwandt, Ankedc.contributor.author
AuthorBiester, Torbendc.contributor.author
AuthorHeidtmann, Bettinadc.contributor.author
AuthorRami-Merhar, Birgitdc.contributor.author
AuthorHaberland, Holgerdc.contributor.author
AuthorMüther, Silvia Mariadc.contributor.author
AuthorKhodaverdi, Semikdc.contributor.author
AuthorHaak, Thomasdc.contributor.author
AuthorHoll, Reinharddc.contributor.author
Date of accession2020-12-02T12:33:30Zdc.date.accessioned
Available in OPARU since2020-12-02T12:33:30Zdc.date.available
Date of first publication2018-02-15dc.date.issued
AbstractObjective To examine glycemic control in youth with type 1 diabetes (T1D) who switched from multiple daily injections (MDI) to a tubeless insulin pump (Omnipod Insulin Management System, Insulet Corporation, Billerica, Massachusetts) compared to patients who continued MDI therapy over a 3‐year time period. Research Design and Methods This retrospective analysis of the German/Austrian Diabetes Patienten Verlaufsdokumentation registry included data from 263 centers and 2529 patients <20 years (n = 660 tubeless insulin pump; n = 1869 MDI) who initiated treatment on a tubeless insulin pump as of January 1, 2013 and had 1 year of data preswitch from MDI and 3 years of data postswitch to a tubeless pump. Outcomes included the change in glycated hemoglobin (HbA1c), insulin dose, and body mass index (BMI) SD score (SDS). Results Youth with T1D who switched from MDI therapy to a tubeless insulin pump showed better glycemic control at 1 year compared to patients who continued MDI treatment, adjusted mean ± SE: 7.5% ± 0.03% (58 mmol/mol) vs 7.7% ± 0.02% (61 mmol/mol); P < .001, with no between‐group difference at 2 and 3 years. Total daily insulin dose was lower (P < .001) in the tubeless insulin pump group, 0.80 ± 0.01, 0.81 ± 0.01, and 0.85 ± 0.01 U/kg, vs the MDI group, 0.89 ± 0.01, 0.94 ± 0.01, and 0.97 ± 0.01 U/kg, at 1, 2, and 3 years, respectively (all P < .001). BMI SDS increased in both groups and was not different over time. Conclusions Treatment with a tubeless insulin pump in youth with T1D was associated with improvements in glycemic control compared to MDI after 1 year and appears to be an effective alternative to MDI. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-on-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordCSIIdc.subject
KeywordHbA1cdc.subject
KeywordMDIdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDiabetes mellitus, Type 1dc.subject.mesh
MeSHAdolescentdc.subject.mesh
MeSHChilddc.subject.mesh
MeSHInsulin infusion systemsdc.subject.mesh
TitleLong-term study of tubeless insulin pump therapy compared to multiple daily injections in youth with type 1 diabetes: Data from the German/Austrian DPV registrydc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-33920dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-33982-3dc.identifier.urn
GNDDiabetes mellitus Typ 1dc.subject.gnd
GNDInsulinpumpedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publicationhttps://doi.org/10.1111/pedi.12658dc.relation1.doi
Source - Title of sourcePediatric Diabetessource.title
Source - Place of publicationWileysource.publisher
Source - Volume19source.volume
Source - Issue5source.issue
Source - Year2018source.year
Source - From page979source.fromPage
Source - To page984source.toPage
Source - ISSN1399-543Xsource.identifier.issn
Source - eISSN1399-5448source.identifier.eissn
EU projectINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
FundingThe Leona M. and Harry B. Helmsley Charitable Trustuulm.funding
FundingEFPIAuulm.funding
FundingDeutsches Zentrum für Diabetesforschung (DZD)uulm.funding
FundingEuropean Foundation for the Study of Diabetes (EFSD)uulm.funding
FundingKompetenznetz Diabetes Mellitus - BMBF [FKZ 01GI1106]uulm.funding
FundingDeutsche Diabetes Gesellschaft (DDG)uulm.funding
FundingJDRFuulm.funding
Bibliographyuulmuulm.bibliographie


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