Show simple item record

AuthorSchwandt, Ankedc.contributor.author
AuthorBergis, Dominikdc.contributor.author
AuthorDenkinger, Michael D.dc.contributor.author
AuthorGollisch, Katjadc.contributor.author
AuthorSandig, Dirkdc.contributor.author
AuthorStingl, Haralddc.contributor.author
AuthorZimny, Stefandc.contributor.author
AuthorHoll, Reinharddc.contributor.author
Date of accession2020-12-02T10:14:30Zdc.date.accessioned
Available in OPARU since2020-12-02T10:14:30Zdc.date.available
Date of first publication2018-07-19dc.date.issued
AbstractAims: To investigate risk factors for declining renal function among subjects with type-1-diabetes. Methods: Observational study based on data from the diabetes registry DPV. 4,424 type-1-diabetes subjects aged ≥18 years, age at onset <18 years were identified. Modification of Diet in Renal Disease (MDRD) equation was used to estimate glomerular filtration rate (eGFR). Annual rate of renal decline was estimated for each patient using hierarchic linear regression models. Additional regression models were fitted to adjust for covariates. Results: Median age was 26 [Q1; Q3: 21; 39] years. Annual decline of renal function was -1.22 (95% CI: -1.50; -0.94) ml/min/1.73m2. At baseline, higher eGFR was related to more rapid decline compared to impaired or reduced eGFR (GFR≥90: -2.06 (-2.35; -1.76), 60≤GFR<90: 0.45 (0.08; 0.81), GFR<60: 0.52 (-0.24; 1.29) ml/min/1.73m2, p<0.01). During follow-up, highest decline was associated with reduced renal function, whereas lowest decline was related to normal kidney function (p<0.01). Poor metabolic control (p=0.04), hypertension (p<0.01) and albuminuria (p=0.03) were associated with more rapid loss of kidney function. No difference was observed among insulin regimen. Conclusion: Among this large type-1-diabetes cohort, more rapid loss of kidney function was related to higher baseline eGFR, log-term worse metabolic control and diabetic comorbidities.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY-NC-ND 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by-nc-nd/4.0/dc.rights.uri
KeywordType-1-Diabetesdc.subject
KeywordKidney functiondc.subject
KeywordRenal declinedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDiabetes mellitus, Type 1dc.subject.mesh
MeSHKidneydc.subject.mesh
MeSHDiabetic nephropathiesdc.subject.mesh
TitleRisk factors for decline in renal function among young adults with type 1 diabetesdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-33916dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-33978-4dc.identifier.urn
GNDDiabetes mellitus Typ 1dc.subject.gnd
GNDNierenfunktiondc.subject.gnd
GNDNierenkrankheitdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
InstitutionBethesda Geriatrische Klinik Ulmuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withDeutsches Zentrum für Diabetesforschung (DZD)uulm.cooperation
In cooperation withUniversitätsklinikum Frankfurtuulm.cooperation
In cooperation withUniversitätsmedizin Göttingenuulm.cooperation
In cooperation withHeinrich-Heine-Universität Düsseldorfuulm.cooperation
In cooperation withHelios Kliniken Schwerinuulm.cooperation
DOI of original publication10.1016/j.jdiacomp.2018.07.007dc.relation1.doi
Source - Title of sourceJournal of Diabetes and its Complicationssource.title
Source - Place of publicationElseviersource.publisher
Source - Volume32source.volume
Source - Issue10source.issue
Source - Year2018source.year
Source - From page940source.fromPage
Source - To page946source.toPage
Source - ISSN1056-8727source.identifier.issn
Source - eISSN1873-460Xsource.identifier.eissn
EU project uulmINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
Bibliographyuulmuulm.bibliographie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record