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AuthorSousa, Gideon dedc.contributor.author
AuthorPrinz, Nicoledc.contributor.author
AuthorBecker, Mariannedc.contributor.author
AuthorDürr, Renatedc.contributor.author
AuthorFaller, Utadc.contributor.author
AuthorMeraner, Dagmardc.contributor.author
AuthorHeise, Nicolaidc.contributor.author
AuthorEngelmann, Illadc.contributor.author
AuthorBruckmayer, Herbertdc.contributor.author
AuthorWiemann, Dagobertdc.contributor.author
AuthorFritsch, Mariadc.contributor.author
AuthorStratmann, Bernddc.contributor.author
AuthorHoll, Reinharddc.contributor.author
Date of accession2020-12-01T14:38:55Zdc.date.accessioned
Available in OPARU since2020-12-01T14:38:55Zdc.date.available
Date of first publication2018-07-10dc.date.issued
AbstractAims: We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. Methods: 139 patients with diabetes and AIH were analyzed and compared to 437728 patients with diabetes without AIH. Results: The prevalence of AIH in patients with T1DM (44.8/100,000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100,000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p<0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p<0.001 resp. p=0.03) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p <0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p<0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p<0.001) compared to diabetes patients without AIH. Conclusions: AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordAutoimmune thyroid diseasedc.subject
KeywordClinical outcomedc.subject
KeywordDiabetes treatmentdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDiabetes mellitus, Type 1dc.subject.mesh
MeSHDiabetes mellitus, Type 2dc.subject.mesh
MeSHThyroid diseasesdc.subject.mesh
MeSHTreatment outcomedc.subject.mesh
TitleDiabetes mellitus and autoimmune hepatitis: demographical and clinical description of a relatively rare phenotypedc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-33913dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-33975-6dc.identifier.urn
GNDDiabetes mellitus Typ 1dc.subject.gnd
GNDDiabetes mellitus Typ 2dc.subject.gnd
GNDAutoimmunthyreoiditisdc.subject.gnd
GNDTherapieerfolgdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.1055/a-0631-2468dc.relation1.doi
Source - Title of sourceHormone and Metabolic Researchsource.title
Source - Place of publicationThieme Gruppesource.publisher
Source - Volume50source.volume
Source - Issue7source.issue
Source - Year2018source.year
Source - From page568source.fromPage
Source - To page574source.toPage
Source - ISSN0018-5043source.identifier.issn
Source - eISSN1439-4286source.identifier.eissn
EU project uulmINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
Bibliographyuulmuulm.bibliographie


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