• English
    • Deutsch
View Item 
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  • English 
    • English
    • Deutsch
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Diabetes mellitus and autoimmune hepatitis: demographical and clinical description of a relatively rare phenotype

Thumbnail
Download
DeSousa_et_al_2018.p ... (809.2Kb)
Erstveröffentlichung
2018-07-10
DOI
10.18725/OPARU-33913
Wissenschaftlicher Artikel


Authors
Sousa, Gideon de
Prinz, Nicole
Becker, Marianne
Dürr, Renate
Faller, Uta
et al.
Faculties
Medizinische Fakultät
Institutions
Institut für Epidemiologie und Medizinische Biometrie
Published in
Hormone and Metabolic Research ; 50 (2018), 7. - S. 568-574. - ISSN 0018-5043. - eISSN 1439-4286
Link to original publication
https://dx.doi.org/10.1055/a-0631-2468
Peer review
ja
Document version
acceptedVersion
License
Standard
https://oparu.uni-ulm.de/xmlui/license_v3
Abstract
Aims: We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. Methods: 139 patients with diabetes and AIH were analyzed and compared to 437728 patients with diabetes without AIH. Results: The prevalence of AIH in patients with T1DM (44.8/100,000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100,000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p<0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p<0.001 resp. p=0.03) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p <0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p<0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p<0.001) compared to diabetes patients without AIH. Conclusions: AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT.
Funding information
EFPIA
JDRF
The Leona M. and Harry B. Helmsley Charitable Trust
European Foundation for the Study of Diabetes (EFSD)
Deutsches Zentrum für Diabetesforschung (DZD)
etc.
EU Project
INNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797
Subject Headings
Diabetes mellitus Typ 1 [GND]
Diabetes mellitus Typ 2 [GND]
Autoimmunthyreoiditis [GND]
Therapieerfolg [GND]
Diabetes mellitus, Type 1 [MeSH]
Diabetes mellitus, Type 2 [MeSH]
Thyroid diseases [MeSH]
Treatment outcome [MeSH]
Keywords
Autoimmune thyroid disease; Clinical outcome; Diabetes treatment
Dewey Decimal Group
DDC 610 / Medicine & health

Metadata
Show full item record

Citation example

Sousa, Gideon de et al. (2020): Diabetes mellitus and autoimmune hepatitis: demographical and clinical description of a relatively rare phenotype. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-33913

Other citation formats


This could also interest you:

  • Improved Glycemic Control in a Patient Group Performing 7-Point Profile Self-Monitoring of Blood Glucose and Intensive Data Documentation: An Open-Label, Multicenter, Observational Study 

    Sieber, Jochen et al. (2017)
    Wissenschaftlicher Artikel

  • A description of clinician reported diagnosis of type 2 diabetes and other non-type 1 diabetes included in a large international multicentered pediatric diabetes registry (SWEET) 

    Pacaud, Daniele et al. (2016)
    Wissenschaftlicher Artikel

  • Five heterogeneous HbA1c trajectories from childhood to adulthood in youth with type 1 diabetes from three different continents: A group-based modeling approach 

    Clements, Mark A. et al. (2019)
    Wissenschaftlicher Artikel


About OPARU | Contact Us
Impressum | Privacy statement
 

 

Advanced Search

Browse

All of OPARUCommunities & CollectionsFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFundingThis CollectionFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFunding

My Account

LoginRegister

Statistics

View Usage Statistics

About OPARU | Contact Us
Impressum | Privacy statement