Diabetes mellitus and autoimmune hepatitis: demographical and clinical description of a relatively rare phenotype

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Erstveröffentlichung
2018-07-10
Wissenschaftlicher Artikel
Authors
Sousa, Gideon de
Prinz, Nicole
Becker, Marianne
Dürr, Renate
Faller, Uta
Faculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometriePublished in
Hormone and Metabolic Research ; 50 (2018), 7. - S. 568-574. - ISSN 0018-5043. - eISSN 1439-4286
Link to original publication
https://dx.doi.org/10.1055/a-0631-2468Peer review
ja
Document version
acceptedVersion
Abstract
Aims: We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry.
Methods: 139 patients with diabetes and AIH were analyzed and compared to 437728 patients with diabetes without AIH.
Results: The prevalence of AIH in patients with T1DM (44.8/100,000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100,000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p<0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p<0.001 resp. p=0.03) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p <0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p<0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p<0.001) compared to diabetes patients without AIH.
Conclusions: AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT.
Funding information
EFPIA
JDRF
The Leona M. and Harry B. Helmsley Charitable Trust
European Foundation for the Study of Diabetes (EFSD)
Deutsches Zentrum für Diabetesforschung (DZD)
etc.
JDRF
The Leona M. and Harry B. Helmsley Charitable Trust
European Foundation for the Study of Diabetes (EFSD)
Deutsches Zentrum für Diabetesforschung (DZD)
etc.
EU Project
INNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797
Subject Headings
Diabetes mellitus Typ 1 [GND]Diabetes mellitus Typ 2 [GND]
Autoimmunthyreoiditis [GND]
Therapieerfolg [GND]
Diabetes mellitus, Type 1 [MeSH]
Diabetes mellitus, Type 2 [MeSH]
Thyroid diseases [MeSH]
Treatment outcome [MeSH]
Keywords
Autoimmune thyroid disease; Clinical outcome; Diabetes treatmentDewey Decimal Group
DDC 610 / Medicine & healthMetadata
Show full item recordCitation example
Sousa, Gideon de et al. (2020): Diabetes mellitus and autoimmune hepatitis: demographical and clinical description of a relatively rare phenotype. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-33913
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