Noncatalytic Bruton's tyrosine kinase activates PLC?(2) variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells

Erstveröffentlichung

2020

Authors

Wist, Martin

Meier, Laura

Gutman, Orit

Haas, Jennifer

Endres, Sascha

et al.

Wissenschaftlicher Artikel

Published in

Journal of Biological Chemistry ; 295 (2020), 17. - S. 5717-5736. - ISSN 0021-9258. - eISSN 1083-351X

Link to publication

https://dx.doi.org/10.1074/jbc.RA119.011946

Faculties

Medizinische Fakultät

Institutions

UKU. Institut für Pharmakologie und Toxikologie
Massenspektrometrie und Proteomics
UKU. Klinik für Innere Medizin III
UKU. Institut für Immunologie

Subject headings

[Free subject headings]: calcium | drug resistance | phospholipase C | phosphoinositide | inositol phospholipid | inositol phosphate | Rac (Rac GTPase) | tyrosine?protein kinase (tyrosine kinase) | B-cell receptor (BCR) | B-cell signaling | Bruton's tyrosine kinase (BTK) | chronic lymphocytic leukemia (CLL) | ibrutinib | PHOSPHOLIPASE-C-GAMMA | LIPID RAFTS | PHOSPHORYLATION SITES | C-BETA(2) ACTIVITY | CALCIUM-RELEASE | RECEPTOR | BTK | C-GAMMA(2) | BLNK | MUTATIONS
[DDC subject group]: DDC 570 / Life sciences

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