No beneficial effect of all-trans retinoic acid in previous non-responder patients with chronic hepatitis C: The ATRACTION study, a phase II randomised trial

Schuchmann, Marcus; Kittner, Jens M.; Schlaak, Joerg F.; Klass, Dietmar M.; Eisenbach, Christoph; Berg, Thomas; Trautwein, Christian; Guenther, Rainer; Zeuzem, Stefan; Goesseringer, Roger; Ehrlich, Anne; Neumann, Konrad; Wachtlin, Daniel; Sprinzl, Martin F.; Zimmermann, Tim; Boecher, Wulf O.; Galle, Peter R.

Erstveröffentlichung

2013

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Wissenschaftlicher Artikel

Autoren

Schuchmann, Marcus

Kittner, Jens M.

Schlaak, Joerg F.

Klass, Dietmar M.

Eisenbach, Christoph

et al.

Institutionen

UKU. Klinik für Innere Medizin I

Erschienen in

Digestive and liver disease ; 45 (2013), 4. - S. 323-329. - ISSN 1590-8658. - eISSN 1878-3562

Link zur Veröffentlichung

https://dx.doi.org/10.1016/j.dld.2012.11.006

Förderinformationen

Roche Pharma AG, Germany
Grant "Clinical Trial Centres, IZKS Mainz" of German Federal Ministry of Education and Research [FKN 01KN1103]

Schlagwörter

All-trans retinoic acid; Chronic hepatitis C; Efficacy; Genotype 1; Mathematical model of viral kinetics; Non-response; Randomised clinical trial; Safety; Tolerability; GASTROINTESTINAL GLUTATHIONE-PEROXIDASE; ACUTE PROMYELOCYTIC LEUKEMIA; OXIDATIVE STRESS; VIRAL DYNAMICS; INTERFERON; MECHANISMS; EXPRESSION; RETREATMENT; RIBAVIRIN; INJURY

DDC-Sachgruppe

DDC 610 / Medicine & health

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