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AuthorPötschke, Christinadc.contributor.author
Date of accession2016-03-15T10:40:33Zdc.date.accessioned
Available in OPARU since2016-03-15T10:40:33Zdc.date.available
Year of creation2014dc.date.created
AbstractIn this work the electrophysiological properties of SN DA neurons from juvenile and adult WT and CaV1.3 KO mice were studied in in vitro brain slices with patch-clamp techniques (whole-cell, perforated-patch and on-cell). The data indicates that CaV1.3 L-type calcium channels, and the related calcium signalling, are important for the AHP of murine SN DA neurons, as well as for determining their maximal firing frequency, as buffering internal calcium seemed to abolish the normally present depolarisation block in those neurons. Furthermore, experiments analysing the D2-autoreceptor response of SN DA neurons from juvenile mice revealed that the general loss of the L-type calcium channel CaV1.3 was compensated via T-type calcium channel activity in CaV1.3 KO mice. The compensatory T-type calcium channel activity enhances calcium mediated NCS-1 (neuronal calcium sensor 1)/D2-autoreceptor interaction and thus prevents the D2-autoreceptor desensitization in SN DA neurons from juvenile CaV1.3 KO mice.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordCaV1.3dc.subject
KeywordDopaminergic midbrain neuronsdc.subject
KeywordL-type calcium channelsdc.subject
KeywordT-type calcium channelsdc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
LCSHCalcium channelsdc.subject.lcsh
LCSHMicedc.subject.lcsh
MeSHDopaminedc.subject.mesh
MeSHElectrophysiologydc.subject.mesh
MeSHNeuronal calcium-sensor proteinsdc.subject.mesh
TitleCompensatory T-type calcium channel activity alters the dopamine D2-autoreceptor response of dopaminergic substantia nigra neurons from juvenile CaV1.3 KO mice.dc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-3298dc.identifier.doi
PPN796784922dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-92087dc.identifier.urn
GNDCalciumkanaldc.subject.gnd
GNDDopamindc.subject.gnd
GNDElektrophysiologiedc.subject.gnd
GNDSubstantia nigradc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2014-08-27T15:20:11Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.777uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID9208uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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