• English
    • Deutsch
View Item 
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  • English 
    • English
    • Deutsch
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Repurposing the alcohol-deterrent drug Disulfiram for the radiotherapy of glioblastoma using an in vitro model of fractionated γ-radiation

Thumbnail
Download
Dissertation_Stroh.p ... (3.964Mb)
Erstveröffentlichung
2020-08-21
DOI
10.18725/OPARU-32622
Dissertation


Authors
Stroh, Sebastien Nicolas
Referee
Debatin, Klaus-Michael
Halatsch, Marc-Eric
Faculties
Medizinische Fakultät
Institutions
UKU. Klinik für Kinder- und Jugendmedizin
UKU. Klinik für Neurochirurgie
License
Standard
https://oparu.uni-ulm.de/xmlui/license_v3
Abstract
Glioblastoma (GB) is the most common primary brain tumor in adults. It is also one of the most lethal and devastating malignancy with a median patient survival of 14 months despite surgical resection and radiochemotherapy. Recent data has suggested that radiotherapy may trigger treatment resistance by promoting the diffuse invasive phenotype of GB, possibly through NF-kB. The alcohol-deterring drug Disulfiram was repurposed in cancer therapy for its antiinvasive properties on GB cells through NF-kB-inhibition, and is therefore an ideal combination candiate with radiotherapy. The purpose of this work is to find out whether the rational combination of Disulfiram and radiation may also have an impact on cell death and growth retardation. Establishing in a first step an in vitro model of radiotherapy, I will find evidence of distinct biological effects of the mostly used single dose radiation delivery vs. the fractionated dose delivery. In a second part, the combination treatment of Disulfiram and radiation will be investigated using the previously established model of fractionated radiation. The endpoints of cell death, growth retardation and cell cycle distribution will be considered. At last, the role of NF-kB in cell death and growth retardation after radiation and combination treatment of Disulfiram and IR will be examined.
Date created
2020
Subject Headings
Glioblastom [GND]
Strahlentherapie [GND]
Disulfiram [GND]
Glioblastoma [MeSH]
Radiotherapy [MeSH]
Disulfiram; Therapeutic use [MeSH]
Dewey Decimal Group
DDC 610 / Medicine & health

Metadata
Show full item record

Citation example

Stroh, Sebastien Nicolas (2020): Repurposing the alcohol-deterrent drug Disulfiram for the radiotherapy of glioblastoma using an in vitro model of fractionated γ-radiation. Open Access Repositorium der Universität Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-32622

Other citation formats



About OPARU | Contact Us
Impressum | Privacy statement
 

 

Advanced Search

Browse

All of OPARUCommunities & CollectionsFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFundingThis CollectionFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFunding

My Account

LoginRegister

Statistics

View Usage Statistics

About OPARU | Contact Us
Impressum | Privacy statement