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AuthorLaubner, Katharinadc.contributor.author
AuthorRiedel, Ninadc.contributor.author
AuthorFink, Katharinadc.contributor.author
AuthorHoll, Reinharddc.contributor.author
AuthorWelp, Reinharddc.contributor.author
AuthorKempe, Hans-Peterdc.contributor.author
AuthorLautenbach, Annedc.contributor.author
AuthorSchlensak, Matthiasdc.contributor.author
AuthorStengel, Rainerdc.contributor.author
AuthorEberl, Thomasdc.contributor.author
AuthorDederichs, Frankdc.contributor.author
AuthorSchwacha, Henningdc.contributor.author
AuthorSeufert, Jochendc.contributor.author
AuthorAberle, Jensdc.contributor.author
Date of accession2020-07-31T07:24:37Zdc.date.accessioned
Available in OPARU since2020-07-31T07:24:37Zdc.date.available
Date of first publication2018-04-23dc.date.issued
AbstractAims: The duodenal-jejunal bypass liner (DJBL) is an endoscopic device mimicking surgical duodenal-jejunal bypass, and is indicated for the treatment of obesity-associated type 2 diabetes mellitus. This analysis was conducted to evaluate the efficacy and safety of the DJBL in comparison to lifestyle changes and antidiabetic drugs. Materials and methods: To determine the efficacy and long-term safety of the DJBL, data concerning 235 obese patients with type 2 diabetes mellitus from the German DJBL registry were analysed. For comparison with standard treatment, propensity-score-matching with patients from the German DPV registry, including the matching parameters sex, age, diabetes duration, baseline BMI and baseline HbA1c, was applied. The final matched cohort consisted of 111 patients in the DJBL group and 222 matched control DPV patients. Results: Mean treatment time with the DJBL was 47.5 ± 12.2 weeks, mean BMI reduction was 5.0 kg/m2 (P < .001) and mean HbA1c reduction was 1.3% (11.9 mmol/mol) (P < .001). Reduction of antidiabetic medications and improvements in other metabolic and cardiovascular risk parameters was observed. In comparison to the matched control group, mean reductions in HbA1c (-1.37% vs -0.51% [12.6 vs 3.2 mmol/mol]; P < .0001) and BMI (-3.02 kg/m2 vs -0.39 kg/m2 ; P < .0001) were significantly higher. Total cholesterol, LDL cholesterol and blood pressure were also significantly better. Conclusion: This study provides the largest, so far, hypothesis-generating evidence for a putative positive risk/benefit ratio for treatment of obese patients with type 2 diabetes mellitus with the DJBL as an alternative treatment option for this patient population. © 2018 John Wiley & Sons Ltd.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordGlycaemic controldc.subject
KeywordWeight controldc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHObesity; Therapydc.subject.mesh
MeSHDiabetes mellitus, Type 2dc.subject.mesh
TitleComparative efficacy and safety of the duodenal-jejunal bypass liner in obese patients with type 2 diabetes mellitus : a case control studydc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-32432dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-32494-6dc.identifier.urn
GNDFettsuchtdc.subject.gnd
GNDTherapiedc.subject.gnd
GNDDiabetes mellitus Typ 2dc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withAlbert-Ludwigs-Universität Freiburguulm.cooperation
In cooperation withUniversitätsklinikum Hamburg-Eppendorfuulm.cooperation
In cooperation withDeutsches Zentrum für Diabetesforschung (DZD)uulm.cooperation
In cooperation withKnappschaftskrankenhaus Bottropuulm.cooperation
In cooperation withDiabetologikum Ludwigshafenuulm.cooperation
In cooperation withSchön Klinik Düsseldorf SE & Couulm.cooperation
In cooperation withDiakonissenanstalt Emmausuulm.cooperation
In cooperation withDonau-Ries Klinik Donauwörthuulm.cooperation
In cooperation withMarienhospital Gelsenkirchenuulm.cooperation
In cooperation withKath. Kliniken Hagenuulm.cooperation
Is Supplemented Byhttps://dom-pubs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fdom.13300&file=dom13300-sup-0001-Tables.docxuulm.relation.isSupplementedBy
DOI of original publication10.1111/dom.13300dc.relation1.doi
Source - Title of sourceDiabetes, Obesity and Metabolismsource.title
Source - Place of publicationWileysource.publisher
Source - Volume20source.volume
Source - Issue8source.issue
Source - Year2018source.year
Source - From page1868source.fromPage
Source - To page1877source.toPage
Source - ISSN1462-8902source.identifier.issn
Source - eISSN1463-1326source.identifier.eissn
EU projectDIRECT / DIabetes REsearCh on patient sTratification / EC / FP7 / 115317uulm.projectEU
EU projectINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
FundingGI Dynamics Inc., Lexington, MD, USAuulm.funding
FundingDiabeteszentrum Forchheimuulm.funding
FundingDeutsche Diabetes Gesellschaft (DDG)uulm.funding
FundingIMI-JU DIRECTuulm.funding
FundingEuropean Foundation for the Study of Diabetes (EFSD)uulm.funding
FundingBundesministerium für Bildung und Forschung [FKZ 01GI1106]uulm.funding
FundingKompetenznetz Diabetes mellitus (Competence Network for Diabetes Mellitus) / BMBFuulm.funding
University Bibliographyjauulm.unibibliographie


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