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AuthorBraun, Elisabethdc.contributor.author
AuthorHotter, Dominikdc.contributor.author
AuthorKoepke, Lennartdc.contributor.author
AuthorZech, Fabiandc.contributor.author
AuthorGroß, Rüdigerdc.contributor.author
AuthorSparrer, Konstantindc.contributor.author
AuthorMüller, Janisdc.contributor.author
AuthorPfaller, Christiandc.contributor.author
AuthorHeusinger, Elenadc.contributor.author
AuthorWombacher, Rebeckadc.contributor.author
AuthorSutter, Kathrindc.contributor.author
AuthorDittmer, Ulfdc.contributor.author
AuthorWinkler, Michaeldc.contributor.author
AuthorSimmons, Grahamdc.contributor.author
AuthorJakobsen, Martindc.contributor.author
AuthorConzelmann, Karl-Klausdc.contributor.author
AuthorPöhlmann, Stefandc.contributor.author
AuthorMünch, Jandc.contributor.author
AuthorFackler, Oliver Tilldc.contributor.author
AuthorKirchhoff, Frankdc.contributor.author
AuthorSauter, Danieldc.contributor.author
Date of accession2020-07-07T10:09:07Zdc.date.accessioned
Available in OPARU since2020-07-07T10:09:07Zdc.date.available
Date of first publication2019-05-14dc.date.issued
AbstractGuanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the human GBP family. GBP2/5 decrease the activity of the cellular proprotein convertase furin, which mediates conversion of the HIV-1 envelope protein (Env) precursor gp160 into mature gp120 and gp41. Because this process primes HIV-1 Env for membrane fusion, viral particles produced in the presence of GBP2/5 are poorly infectious due to increased incorporation of non-functional gp160. Furin activity is critical for the processing of envelope glycoproteins of many viral pathogens. Consistently, GBP2/5 also inhibit Zika, measles, and influenza A virus replication and decrease infectivity of viral particles carrying glycoproteins of Marburg and murine leukemia viruses. Collectively, our results show that GPB2/5 exert broad antiviral activity by suppressing the activity of the virus-dependency factor furin.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY-NC-ND 4.0dc.rights
KeywordGBPdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHHIVdc.subject.mesh
MeSHImmunity, Innatedc.subject.mesh
TitleGuanylate-Binding proteins 2 and 5 exert broad antiviral activity by inhibiting Furin-Mediated processing of viral envelope proteinsdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-32230dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-32292-2dc.identifier.urn
GNDHIVdc.subject.gnd
GNDAngeborene Immunitätdc.subject.gnd
InstitutionUKU. Institut für Molekulare Virologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withPaul-Ehrlich-Institutuulm.cooperation
In cooperation withUniversitätsklinikum Heidelberguulm.cooperation
In cooperation withUniversität Duisburg-Essenuulm.cooperation
In cooperation withDeutsches Primatenzentrum - Leibnitz-Institut für Primatenforschunguulm.cooperation
In cooperation withUniversity of Californiauulm.cooperation
In cooperation withAarhus Universityuulm.cooperation
In cooperation withLudwig-Maximilians-Universität Münchenuulm.cooperation
In cooperation withGeorg-August-Universität Göttingenuulm.cooperation
In cooperation withDeutsches Zentrum für Infektionsforschunguulm.cooperation
Is Supplemented Byhttps://www.sciencedirect.com/science/article/pii/S2211124719305364?via%3Dihub#app2uulm.relation.isSupplementedBy
DOI of original publication10.1016/j.celrep.2019.04.063dc.relation1.doi
Source - Title of sourceCell Reportssource.title
Source - Place of publicationCell Presssource.publisher
Source - Volume27source.volume
Source - Issue7source.issue
Source - Year2019source.year
Source - From page2092source.fromPage
Source - To page2104source.toPage
Source - ISSN2211-1247source.identifier.issn
EU projectVIAR / Virus-induced autophagy restriction / EC / H2020 / 794803uulm.projectEU
FundingBausteinprogramm der Medizinischen Fakultät / Universität Ulmuulm.funding
FundingSFB 1279 / Nutzung des menschlichen Peptidoms für die Entwicklung neuer antimikrobieller und anti-Krebs Therapeutika / DFG / SFB / 316249678uulm.funding
FundingSPP 1923 / Innate Sensing and Restriction of Retroviruses / DFGuulm.funding
FundingTRR 83 / Molekulare Architektur und zelluläre Funktionen von Lipid/Protein Komplexen / DFG [TRR237]uulm.funding
FundingSFB 548 / Analyse und Modulation allergischer und autoimmunologischer Krankheiten / DFG [Ki548/16]uulm.funding
FundingTRR 237 / Nukleinsäure-Immunität / DFG [TRR237]uulm.funding
FundingBaden-Württemberg Stiftung, Germanyuulm.funding
FundingGSC 270 / Internationale Graduiertenschule für Molekulare Medizin Ulm (IGradU) / DFG / GSC / 53244728uulm.funding
University Bibliographyjauulm.unibibliographie


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