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AuthorReinauer, Christinadc.contributor.author
AuthorBollow, Estherdc.contributor.author
AuthorFröhlich-Reiterer, Elkedc.contributor.author
AuthorLaubner, Katharinadc.contributor.author
AuthorBergis, Dominikdc.contributor.author
AuthorSchöfl, Christofdc.contributor.author
AuthorKempe, Hans-Peterdc.contributor.author
AuthorHummel, Michaeldc.contributor.author
AuthorHennes, Piadc.contributor.author
AuthorGollisch, Katjadc.contributor.author
AuthorHaberland, Holgerdc.contributor.author
AuthorDatz, Nicoledc.contributor.author
AuthorMeissner, Thomasdc.contributor.author
AuthorHoll, Reinhard Wdc.contributor.author
Date of accession2020-07-03T14:56:39Zdc.date.accessioned
Available in OPARU since2020-07-03T14:56:39Zdc.date.available
Date of first publication2017-09-19dc.date.issued
AbstractContext: While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective: The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Design and Setting: Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age. Results: The age at T1D manifestation in PCOS patients was later than in the control group (14.9±8.2 vs. 11.8±7.0 years, p<0.001). PCOS patients had higher BMI-SDS (0.92±0.11 vs. 0.38±0.01, p<0.001), metformin and oral contraceptives were used more frequently (p<0.001). A1c levels were significantly lower (7.92 +/− 0.23% vs. 8.43±0.01%, p<0.05) despite of lower insulin requirements (0.76±0.04 IU/kg/d vs. 0.84±0.00 IU/kg/d, p<0.05). In the PCOS group, higher rates of dyslipi-demia (63.4 vs. 48.7%, p=0.032) and thyroid disorders (42.2% vs. 21.2%, p<0.001) were present. Discussion: While patients with T1D and comorbid PCOS showed features of a “type 1.5 diabetes” phenotype, insulin requirements per kg body weight were not higher and metabolic control was better, which could be explained only partially by additional metformin therapy. A more precise genetic and metabolic characterisation of these patients is needed to answer open questions on the underlying autoimmune process and residual ß-cell function. © Georg Thieme Verlag KG Stuttgart · New York.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHPolycystic ovary syndromedc.subject.mesh
MeSHObesitydc.subject.mesh
MeSHDiabetes mellitusdc.subject.mesh
TitlePolycystic ovary syndrome (PCOS) in juvenile and adult type 1 diabetes in a German/Austrian cohortdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-32221dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-32283-0dc.identifier.urn
GNDStein-Leventhal-Syndromdc.subject.gnd
GNDÜbergewichtdc.subject.gnd
GNDDiabetes mellitusdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
DCMI TypeDatasetuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.1055/s-0043-104701dc.relation1.doi
Source - Title of sourceExperimental and Clinical Endocrinology and Diabetessource.title
Source - Place of publicationThieme Gruppesource.publisher
Source - Volume125 (2017)source.volume
Source - Issue10source.issue
Source - Year2017source.year
Source - From page661source.fromPage
Source - To page668source.toPage
Source - ISSN0947-7349source.identifier.issn
Source - eISSN1439-3646source.identifier.eissn
EU projectDIRECT / DIabetes REsearCh on patient sTratification / EC / FP7 / 115317uulm.projectEU
EU projectINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
FundingEuropean Foundation for the Study of Diabetes (EFSD)uulm.funding
FundingGerman Diabetes Association (DDG)uulm.funding
FundingHeinz Burger-Busing foundationuulm.funding
FundingKrankheitsbezogenes Kompetenznetz Diabetes mellitus, Thema Pädiatrischer Diabetes - TP15, 16a / BMBF [FKZ 01GI1106]uulm.funding
University Bibliographyjauulm.unibibliographie


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