An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

Danielsson,  Angelika; Elgue, G.; Nilsson, Britt-Marie; Nilsson, Bo; Lambris, John D.; Totterman, Thomas; Kochanek, Stefan; Kreppel,  Florian; Essand, Magnus

Erstveröffentlichung

2010

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Wissenschaftlicher Artikel

Autoren

Danielsson, Angelika

Elgue, G.

Nilsson, Britt-Marie

Nilsson, Bo

Lambris, John D.

et al.

Institutionen

UKU. Abteilung für Gentherapie

Erschienen in

Gene Therapy ; 17 (2010), 6. - S. 752-762. - ISSN 0969-7128. - eISSN 1476-5462

Link zur Veröffentlichung

https://dx.doi.org/10.1038/gt.2010.18

Schlagwörter

human blood model; PEGylated adenovirus; immune response; cytokines; complement system; cell adhesion; POLYETHYLENE-GLYCOL MODIFICATION; INNATE IMMUNE-RESPONSES; PHASE-I TRIAL; ONCOLYTIC ADENOVIRUS; NEUTRALIZING ANTIBODIES; HUMAN-COMPLEMENT; GENE-TRANSFER; PROSTATE-CANCER; CLINICAL-TRIALS; VECTORS

DDC-Sachgruppe

DDC 570 / Life sciences
DDC 610 / Medicine & health

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