An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

Erstveröffentlichung
2010
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Wissenschaftlicher Artikel


Authors
Danielsson, Angelika
Elgue, G.
Nilsson, Britt-Marie
Nilsson, Bo
Lambris, John D.
et al.
Institutions
UKU. Abteilung für Gentherapie
Published in
Gene Therapy ; 17 (2010), 6. - S. 752-762. - ISSN 0969-7128. - eISSN 1476-5462
Link to publication
https://dx.doi.org/10.1038/gt.2010.18
Funding information
Swedish Cancer Society [CAN 2007/885, CAN 2009/55]
Swedish Research Councill [K2008-68X-15270-04-3]
Gunnar Nilsson's Cancer Foundation [E50/08]
European Community [LSHB-CT-2004-512087]
Keywords
human blood model; PEGylated adenovirus; immune response; cytokines; complement system; cell adhesion; POLYETHYLENE-GLYCOL MODIFICATION; INNATE IMMUNE-RESPONSES; PHASE-I TRIAL; ONCOLYTIC ADENOVIRUS; NEUTRALIZING ANTIBODIES; HUMAN-COMPLEMENT; GENE-TRANSFER; PROSTATE-CANCER; CLINICAL-TRIALS; VECTORS
Dewey Decimal Group
DDC 570 / Life sciences
DDC 610 / Medicine & health
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