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AuthorBaumann, Lisadc.contributor.author
Date of accession2016-03-15T09:08:35Zdc.date.accessioned
Available in OPARU since2016-03-15T09:08:35Zdc.date.available
Year of creation2012dc.date.created
AbstractHippocampal structures play an important role in memory and learning. The dentate gyrus, contributing in particular to the formation of new memories, is one of only two brain regions where adult neurogenesis occurs. Adult neurogenesis is a multistep process and thightly regulated by extrinsic and intrinsic factors such as transcription factors. Previously it has been shown that the zinc finger transcription factor Bcl11b/CTIP2, expressed specifically in postmitotic granule cells of the dentate gyrus, plays an essential role during postnatal development of the hippocampus. As a consequence, Bcl11b/CTIP2 also affects learning behaviour. Furthermore expression of Bcl11b/CTIP2 continues throughout life. In this thesis it is reported that Bcl11b is not only required during postnatal development of the dentate gyrus, but also during adult neurogenesis. Adult mice harboring a forebrain-specific deletion of Bcl11b/CTIP2 exhibit a progressively smaller size of the dentate gyrus and reduced number of granule cells. It is shown that this phenotype is independent of the survival of existing neurons but due to reduced adult neurogenesis. This reduction is caused either by a decreased proliferation rate or a depletion of the stem cell compartment. In addition the forebrain-specific ablation of Bcl11b/CTIP2 results in arrested differentiation of adult born granule cells. Taken together these data strongly suggest an important role of Bcl11b/CTIP2 in adult neurogenesis.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordAdulte Neurogenesedc.subject
KeywordBcl11bdc.subject
KeywordCTIP2dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDentate gyrusdc.subject.mesh
MeSHHippocampusdc.subject.mesh
MeSHNeurogenesis; In adulthooddc.subject.mesh
TitleFunktionelle Analyse des Zinkfingertranskriptionsfaktors Bcl11b während der adulten Neurogenese im Gyrus dentatusdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-3018dc.identifier.doi
PPN779001184dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-88114dc.identifier.urn
GNDGyrus dentatusdc.subject.gnd
GNDZink-Finger-Proteinedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2014-02-12T10:26:35Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.487uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID8811uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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