Einfluss der Fettleber auf den Zusammenhang zwischen Alkoholkonsum und systemischen Entzündungsmarkern in einer bevölkerungsbezogenen Studie
Wolff, Stefan Alexander
Introduction: Moderate alcohol intake is associated with a lower risk of coronary heart disease, presumably by antiinflammatory effects. A pre-existing fatty liver might modify these effects. Purpose: We examinated the relationship between self-reported alcohol-intake and several inflammatory markers and OxLDL and the potential effect of a pre-existing fatty liver on this relationship. Methods: A subsample of 515 men and women randomly drawn from the EMIL-study (Echinococcus Multilocularis In Leutkirch) were measured anthropometrically, underwent abdominal sonography plus a standardized interview and donated a blood sample. OxLDL and IL-6 were measured by ELISA. CRP and fibrinogen were determined nephelometrically. Adiponectine levels were determined using a sandwich enzyme immunoassay. Results: Alcohol consumption modifies the researched markers in a complex manner, indicating an anti-inflammatory effect of moderate alcohol consumption. Pre-existing fatty liver modifies this relationship in a complex manner and is associated with higher concentrations of inflammatory markers. The prevalence of fatty liver is lowest in individuals with moderate daily alcohol intake.
Subject HeadingsAlkoholkonsum [GND]
Koronare Herzkrankheit [GND]
Alcohol drinking [MeSH]
Coronary disease; Prevention and control [MeSH]
Fatty liver [MeSH]