Neural crest-derived sympathoadrenergic-like progenitors of the postnatal murine adrenal gland
The aim of this study was to identify and characterize a novel experimental source of neural crest-derived stem and progenitor cells, which are not only essential for development of the sympathetic peripheral nervous system, but also play a key role in the genesis of neuroblastoma, the most common and frequently lethal extracranial solid tumor in childhood. Therefore, experimental access to these stem cells is crucial, however, the derivation of neural crest-derived stem and progenitor cells from sources, such as embryonic stem cells and peripheral tissue, is complicated by cellular heterogeneity and low yield. Thus, isolating sufficient numbers of these progenitor cells for investigations had so far remained elusive. The studies in this thesis focused on describing the isolation and characterization of a rare and novel population of neural crest-derived sympathoadrenergic progenitors from postnatal murine adrenal glands. These advances may facilitate investigations about the cell of origin of neuroblastoma.
Subject HeadingsNebenniere [GND]
Adrenal glands [MeSH]
Neural crest [MeSH]
Neuroblastoma; Etiology [MeSH]
Stem cells [MeSH]