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AuthorKhalid, Mohammaddc.contributor.author
Date of accession2016-03-15T09:07:30Zdc.date.accessioned
Available in OPARU since2016-03-15T09:07:30Zdc.date.available
Year of creation2013dc.date.created
AbstractWhether Nef-mediated down-modulation of TCR-CD3 protects lentivirus-infected hosts against damaging high levels of immune activation, is under debate. Since HIV-2 Nef ability to down-modulate the TCR-CD3 greatly varied, some of them were highly efficient while others were impaired and have HIV-1 Nef like phenotype for the function. This wide spectrum of the down-modulation function among the HIV-2 Nefs allowed us to analyze the significance of TCR- CD3 down-modulation and its role in activation of CD4+ T cells. The outline suggests that Nef-mediated down-modulation of TCR-CD3 and CD28 plays role in protection of viremic HIV-2-infected individuals against loss of CD4+ T cells. These two basic functions play role in activation of the cells and seemingly delay the activation induced exhaustion and apoptotic death of virally infected CD4+ T cells. However, in accordance, the significant correlation of the level of Nef-mediated down-modulation of TCR-CD3 and the levels of immune activation in HIV-2-infected individuals with comparably low viral loads have been reported (20). Another remarkable discovery is the identification of naturally occurring HIV-2 nef alleles that are selectively impaired in specific functions like surface modulation of CD4, CD28, CD74, MHC-I and more importantly down-modulation of TCR-CD3. These selectively defective Nefs open up ways to study the role of CD4 down-modulation, T cell activation or antigen presentation in viral immune evasion, and effect of these specific functions in pathogenicity in animal models. These selectively defective Nefs in specific functions can play significant role to study the detailed mechanisms involved in AIDS progression in vivo.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordHIVdc.subject
KeywordTCR-CD3dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHLentivirusdc.subject.mesh
MeSHrac GTP-binding proteinsdc.subject.mesh
TitleEfficient Nef-mediated down-modulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infectiondc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2879dc.identifier.doi
PPN750167467dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-85281dc.identifier.urn
GNDAntigen CD28dc.subject.gnd
GNDGen nefdc.subject.gnd
GNDTyp 2dc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2013-06-06T15:29:40Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.267uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID8528uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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