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AuthorSchlitter, Anne-Mariedc.contributor.author
Date of accession2016-03-15T09:07:00Zdc.date.accessioned
Available in OPARU since2016-03-15T09:07:00Zdc.date.available
Year of creation2010dc.date.created
AbstractNeuroblastoma is thought to originate from neural crest-derived cells. CD57 defines migratory neural crest cells in normal development and is expressed in neuroblastoma. We investigated the role of CD57 expression in neuroblastoma cells ex situ and in situ. Compared to CD57low U-NB1 neuroblastoma cells, CD57high cells developed tumors with decreased latency after orthotopic transplantation into adrenal glands of mice. In addition, CD57high U-NB1 and SK-N-BE(2)-C neuroblastoma cells were also more clonogenic, induced more spheres and were less lineage-restricted. CD57high cells attached better to endothelial cells and showed enhanced invasiveness. While invasion of U-NB1 cells was inhibited by blocking antibodies against CD57, neither invasion of SK-N-BE(2)-C cells nor adhesion of U-NB1 and SK-N-BE(2)-C cells was attenuated. After tail vein injection only CD57high cells generated liver metastases, while overall metastatic rate was not increased as compared to CD57low cells. In stroma-poor neuroblastoma of patients CD57high cells were associated with undifferentiated tumor cells across all stages and tended to be more frequent after chemotherapy. Diese Dissertation beruht auf einer Veröffentlichung in: PLOS ONE, http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042025dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordAntigens, CD57dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHNeoplastic stem cellsdc.subject.mesh
MeSHNeuroblastomadc.subject.mesh
TitleCD57high neuroblastoma cells have characteristics of tumor-initiating cellsdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2814dc.identifier.doi
PPN1651975280dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-83386dc.identifier.urn
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2013-01-16T09:18:54Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.157uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID8338uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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