Structural changes of the outer and inner vestibule of hKv1.3 channels during C type inactivation
Kv1.3 channels play important roles in a variety of tissues. The specific pharmacological modulation of hKv1.3 channels might be useful for controlling the physiological and pathophysiological processes related to this channel. Pharmacological specificity can be achieved by using specific structures or features of hKv1.3 channels. One of the most special features of hKv1.3 channels is the C type inactivated state. Therefore, to be able to rationally design drugs specific for the C type inactivation state of the hKv1.3 channels, it is necessary to characterize the structure as well as the structural changes associated with C type inactivation in hKv1.3 channels. The present work proposes to investigate the structural changes occurring during C type inactivation in the outer and inner pore of the hKv1.3 channels.