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AuthorSchauflinger, Martindc.contributor.author
Date of accession2016-03-15T09:06:10Zdc.date.accessioned
Available in OPARU since2016-03-15T09:06:10Zdc.date.available
Year of creation2012dc.date.created
AbstractWe could show that HCMV morphogenesis is comparable in fibroblasts, endothelial cells and macrophages and that the absence or the functional impairment of the HCMV tegument protein pUL71 is affecting viral morphogenesis in all investigated cell types in a similar manner. pUL71 is associated with membranes within the AC at late stages of infection, and its absence causes impairment of secondary envelopment, morphological alterations of vesicles within the AC, and influences MVBs in infected fibroblasts, HUVEC, and MDM. Particularly a pUL71 palmitoylation site and a leucine zipper like motif are of great importance for pUL71 function and HCMV morphogenesis, while a C-terminal tetra-lysine motif only augments secondary envelopment. In contrast, a Vps4 interacting motif of pUL71seems to be not important for HCMV morphogenesis.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordpUL71dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHCytomegalovirusdc.subject.mesh
MeSHEndothelial cellsdc.subject.mesh
MeSHFibroblastsdc.subject.mesh
MeSHMacrophagesdc.subject.mesh
TitleCharacterization of the Human Cytomegalovirus Protein pUL71 and its Impact on viral Morphogenesis in Fibroblasts, Endothelial Cells and Macrophagesdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2689dc.identifier.doi
PPN719348471dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-80704dc.identifier.urn
GNDCytomegalie-Virusdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2012-07-04T11:35:52Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 12.951uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID8070uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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