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AuthorMirzoyan, Zhasminedc.contributor.author
Date of accession2016-03-15T09:05:15Zdc.date.accessioned
Available in OPARU since2016-03-15T09:05:15Zdc.date.available
Year of creation2013dc.date.created
AbstractThe Drosophila heart is a proven system for studying regulatory genes that are involved in cardiogenesis. The specification and differentiation of cardiac progenitor cells require complex interactions between a number of transcription factors. The Drosophila Iroquois gene complex (Iro-C) consists of three homeobox transcription factors: araucan (ara), caupolican (caup) and mirror (mirr). The Iro-C participates in various developmental processes such as determining positional identity in different tissues in Drosophila. To determine whether the Iro-C also regulates cardiogenesis, the embryonic expression pattern of the Iro-C factors was characterized and heart phenotypes in different Iro-C mutant embryos were analyzed. Detailed expression pattern analysis of the members of the Iro-C revealed the existence of a subpopulation of pericardial cells, which co-express Even-skipped (Eve) and Ara/Caup and a novel set of heart-associated cells that are characterized by the expression of the different members of the Iro-C. Furthermore, the phenotypic studies integrate Iro-C into the network of transcription factors whose concerted action determines a cardiac fate and indicate that the GATA factor Pannier requires Iro-C activity to function in cardiogenesis. Additionally, this study demonstrates that Caup binds to the enhancer region of hand, a bHLH transcription factor expressed in the visceral mesoderm and in the heart, and that Caup regulates the transcriptional activity of a hand reporter construct. Taken together, this work provides a new basis for further studies aiming to decipher the regulatory interactions between the factors that determine different cell fates in the dorsal mesoderm.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordAraucan transcription factordc.subject
KeywordCaupolican transcription factordc.subject
KeywordDorsal mesodermdc.subject
KeywordDrosophila heartdc.subject
KeywordIroquois gene complexdc.subject
KeywordMirr transcription factordc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
LCSHDrosophila; Geneticsdc.subject.lcsh
LCSHHomeobox genesdc.subject.lcsh
TitleIdentification of a role for the iroquois complex in drosophila heart developmentdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2630dc.identifier.doi
PPN77352407Xdc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-87155dc.identifier.urn
GNDGenregulationdc.subject.gnd
GNDTranskriptionsfaktordc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2013-11-08T09:00:51Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.427uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID8715uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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