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AuthorBückle-Vallant, Verena Mariedc.contributor.author
Date of accession2016-03-15T09:05:00Zdc.date.accessioned
Available in OPARU since2016-03-15T09:05:00Zdc.date.available
Year of creation2013dc.date.created
AbstractThe natural precursor of the essential amino acid L-leucine, 2-ketoisocaproate, is often used as a therapeutic agent in infusion solutions for kidney-patients and as integral part of functional food for muscle regeneration. Moreover, 2-ketoisocaproate may serve as precursor for products deriving from this 2-ketoacid, e.g. 3-methylbutanal (isovaleraldehyde), an intermediate for industrial vitamin synthesis, as well as its corresponding alcohol 3-methyl-1-butanol, a potential future biofuel. In the present work, the efficient, growth-coupled production of 2-ketoisocaproate with metabolically engineered Corynebacterium glutamicum strains was pursued. In this context, potential limitations during 2-ketoisocaproate synthesis in C. glutamicum were identified, permitting the directed improvement of the newly constructed strain(s).dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
Keyword2-Ketoisocaproatedc.subject
KeywordFermentative productiondc.subject
KeywordRational strain designdc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
LCSHEnzyme kineticsdc.subject.lcsh
MeSHMetabolic engineeringdc.subject.mesh
Title2-Ketoisocaproate synthesis in Corynebacterium glutamicum and role of the key enzyme isopropylmalate synthasedc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2614dc.identifier.doi
PPN1658497503dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-85275dc.identifier.urn
GNDCorynebacterium glutamicumdc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2014-07-07T12:01:07Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 13.709uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID8527uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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