Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma

Erstveröffentlichung
2020
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Wissenschaftlicher Artikel


Authors
Pruss, Maximilian
Dwucet, Annika
Tanriover, Mine
Hlavac, Michal
Kast, Richard Eric
et al.
Institutions
UKU. Klinik für Neurologie
UKU. Klinik für Kinder- und Jugendmedizin
Published in
British Journal of Cancer. - : Nature Publishing Group, 2020. - ISSN 0007-0920. - eISSN 1532-1827
Link to publication
https://dx.doi.org/10.1038/s41416-020-0759-0
Funding information
United States Department of Health & Human Services, National Institutes of Health (NIH), NIH National Institute of Neurological Disorders & Stroke (NINDS) [K08 NS083732, R01 NS095848, R01 NS102366]
Keywords
APOPTOSIS IN-VITRO; COMBINED INHIBITION; DOSE-ESCALATION; CELL-LINES; BCL-2/BCL-XL; TEMOZOLOMIDE; 2-DEOXY-D-GLUCOSE; RADIOTHERAPY; SENSITIZES; DEATH
Dewey Decimal Group
DDC 610 / Medicine & health
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