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AuthorKeller, Johannesdc.contributor.author
Date of accession2020-02-13T14:36:50Zdc.date.accessioned
Available in OPARU since2020-02-13T14:36:50Zdc.date.available
Year of creation2018dc.date.created
Date of first publication2020-02-13dc.date.issued
AbstractIn Alzheimer’s disease the accumulation of Amyloid beta aggregates promotes microglial activation causing cell damage by releasing reactive oxygen species. Curcuma has been shown to be anti-amyloidogenic, antiinflammatory and antioxidative. To improve the very limited bioavailability as well as the blood-brain barrier crossing, Curcumin loaded polylactide-co-glycolic-acid Nanoparticles were formulated. The Nanoparticles did not inflict significant toxicity on primary hippocampal cell cultures. In groups treated with Curcumin loaded Nanoparticles there was a significant decrease of Amyloid beta aggregates, as well as inflammation and reactive oxygen species.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordTargetingdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHCurcumindc.subject.mesh
MeSHNanoparticlesdc.subject.mesh
MeSHDementiadc.subject.mesh
MeSHAlzheimer diseasedc.subject.mesh
MeSHInflammationdc.subject.mesh
MeSHSynapsesdc.subject.mesh
MeSHAmyloiddc.subject.mesh
MeSHBlood-brain barrierdc.subject.mesh
MeSHOxidative stressdc.subject.mesh
TitleIn vitro characterization of nanoparticles engineered for brain targeted Curcumin delivery as treatment strategy for amyloid induced pathology in Alzheimer's diseasedc.title
Resource typeDissertationdc.type
Date of acceptance2019-11-22dcterms.dateAccepted
RefereeGrabrucker, Andreasdc.contributor.referee
RefereeKnöll, Bernddc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-25257dc.identifier.doi
PPN1690057408dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-25320-4dc.identifier.urn
GNDCurcumindc.subject.gnd
GNDNanopartikeldc.subject.gnd
GNDDemenzdc.subject.gnd
GNDAlzheimerkrankheitdc.subject.gnd
GNDEntzündungdc.subject.gnd
GNDSynapsedc.subject.gnd
GNDAmyloiddc.subject.gnd
GNDBlut-Hirn-Schrankedc.subject.gnd
GNDOxidativer Stressdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Anatomie und Zellbiologieuulm.affiliationSpecific
InstitutionInstitut für Physiologische Chemieuulm.affiliationSpecific
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.1016/j.ijpharm.2017.05.015dc.relation1.doi
University Bibliographyjauulm.unibibliographie


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