Development of large-scale functional networks over the lifespan

Abstract

We investigated the development of large-scale functional networks over the lifespan by examining resting MEG of 53 healthy participants aged 18 - 89. Results show differential developments across the lifespan for low and high frequency networks. Delta frequency (2 - 4 Hz) networks decrease in size, while beta/gamma frequency (16 Hz) networks increase in size with age. The right frontal lobe and bilateral temporal areas were found to be important relay stations in high frequency networks. Normal age-related declines in visual memory and visuoconstructive capabilities were associated with the age-related increase of functional connectivity in both temporal lobes. Wird veröffentlicht in: Neurobiology of aging (2012)