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AuthorHefele, Sulamithdc.contributor.author
Date of accession2016-03-15T06:25:25Zdc.date.accessioned
Available in OPARU since2016-03-15T06:25:25Zdc.date.available
Year of creation2011dc.date.created
AbstractGhrelin, a 28-amino acid peptide, is known as orexigenic hormone. It is secreted from the stomach into the systemic circulation. Central nervous system pathways play a prominent role in mediating ghrelins orexigenic effects. Circulating ghrelin levels increase before food intake or during fasting and decrease after food intake. Several studies have shown that ghrelin regulates metabolic homeostasis of adipose tissue via central mechanisms. Ghrelin has also been shown to have direct effects on adipose tissue. Using the human SGBS preadipocyte cell strain, which has the capacity for adipocyte differentiation in vitro, we tested ghrelin-mediated influences on human adipocyte biology. In our experiments, ghrelin stimulates the proliferation of preadipocytes, but has no effect on adipogenic differentiation. Ghrelin increases basal adipogenesis and inhibits insulin-stimulated adipogenesis. These effects on adipogenesis are mediated by a GSK-3/Akt pathway. Furthermore, ghrelin stimulates expression of the proinflammatory cytokines IL-6 and IL-8 and has no effect on the expression of adiponectin. These findings demonstrate the effect of ghrelin on the adipose mass, the metabolism and the endocrine function of human SGBS preadipocytes. Ghrelin may therefore play an important role in therapy for obesity.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordHuman SGBS preadipocytesdc.subject
KeywordOrexigenic hormonedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAdipose tissuedc.subject.mesh
MeSHObesitydc.subject.mesh
TitleUntersuchungen zum Einfluss von Ghrelin auf die Biologie der Fettzelledc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2346dc.identifier.doi
PPN716615193dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-79409dc.identifier.urn
GNDGhrelindc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2012-05-08T09:12:58Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 12.866uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7940uulm.vtsID
CategoryPublikationenuulm.category


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