Charakterisierung Granzym B-sezernierender B-Zellen

Abstract

Granzyme B is secreted by human benign B cells in response to Interleukin 21 an B cell receptor activation. Granzyme B-secreting B cells were more resistant to apoptosis than unstimulated B cells and Granzyme B was mainly found in viable B cells, suggesting that the primary function of B cell-derived Granzyme B is not self-regulation. Differentiation was associated with a CD19+CD20+CD27-IgD-CD38- phenotype, increased dextran uptake and strong upregulation of molecules involved in cell adhesion (CD54), antigen-presentation (MHC class II) and co-stimulation (CD86). The data indicate that this differentiation serves potential interactions with target cells e.g. virus-infected cells, but not self-regulation.