Untersuchung der Rolle von Alkoholkonsum im Zusammenhang mit Steatosis Hepatis

Abstract

Background: The role of alcohol with regard to hepatic steatosis varies from risk factor to protective factor. Aim: To determine a protective effect of alcohol on hepatic steatosis. Methods: A prospective cross-sectional, population-based study in participants (n = 1542) from the EMIL-Study (54% women; mean age: 42 years, BMI 25,5 kg/m², alcohol users: 65%). Alcohol use was ascertained by a validated questionaire and hepatic steatosis by sonographic examination. Results: In multivariate logistic regression models adjusted for sex, age, body-mass-index and metabolic syndrome low alcohol consumption independently reduced the odds of hepatic steatosis in older subjects by 0.7 (95% CI: 0.488-0.953, P = 0.0248) and women by 0.6 (95% CI: 0.41-0.86, P = 0,0061). Wine reduced the risk for women consuming 1 glas/weekend by 0.5 (95% CI: 0.29-0.84, P = 0,0097) and hard liquor for men at a dose of 4 cl/weekend by 0.1 (95% CI: 0.01-0.81, P = 0.0310). Conclusions: Alcohol can show a protective effect on hepatic steatosis depending on dose, beverage as well as consumer characteristics.