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AuthorKlotz, Matthiasdc.contributor.author
Date of accession2016-03-15T06:25:04Zdc.date.accessioned
Available in OPARU since2016-03-15T06:25:04Zdc.date.available
Year of creation2010dc.date.created
AbstractIntroduction: Septic shock is one of the most common diseases on intensive care units. The recent Surviving Sepsis Campaign international guidelines for management of septic shock suggest norepinephrine or dopamine as first line vasopressor and vasopressin as an alternative. Vasopressin is an effective vasoactive drug due to activating the V1a- receptor. Disadvantages of vasopressin like antidiuresis, hypercoagulation and selective vasodilatation are mediated by the V2- receptor. Material and Methods: We tested a new selective V1a- receptor-agonist in hyperdynamic septic shock compared to norepinephrine. A randomized controlled trial on 25 pigs during 24 hours of faecal-peritoneal induced septic shock. Controll-group (NoA) received only norepinephrine as vasopressor. V1a-group received a V1a- selective agonist as vasopressor and if necessary in addition norepinephrine. Results: V1a-group showed a high demand of norepinephrine to maintain mean arterial pressure. NoA-group showed a fall in mean arterial pressure 18 hours after induction of septic shock. Discussion: Due to a heartrate-limitation of 160 beats per minute norepinephrine-dose couldn’t be increased 18 hours after sepsis induction in NoA-group. Thus the pigs of the NoA-group showed a fall in mean arterial pressure. Based on the high demand of norepinephrine in the V1a-group the effectivity of the V1a- receptor agonist is doubtful.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordGroßtiermodelldc.subject
KeywordVasopressordc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHNorepinephrinedc.subject.mesh
MeSHSepsisdc.subject.mesh
MeSHShock, septicdc.subject.mesh
TitleHämodynamische Beeinflussung des hyperdynamischen septischen Schocks im Großtiermodel - Noradrenalin und ein selektiver V1a-Agonistdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2215dc.identifier.doi
PPN663906768dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-76716dc.identifier.urn
GNDSeptischer Schockdc.subject.gnd
GNDVasopressindc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2011-06-27T08:54:41Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 14.116; W: W-H 12.580uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7671uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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