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AuthorPorr, Andreeadc.contributor.author
Date of accession2016-03-15T06:25:02Zdc.date.accessioned
Available in OPARU since2016-03-15T06:25:02Zdc.date.available
Year of creation2010dc.date.created
AbstractGalectins comprise a family of animal lectin that exhibits affinity for ß-galactosides. 15 galectins have been identified with various biological functions as neoplasic transformation and metastasis. We investigated the expression pattern and subcellular localisation of galectin-1, -3 and galectin-8 in pancreatic carcinoma cell lines. Most of this cell lines expressed considerable amounts of galectin-1, -3 and -8. RT-PCR analyses exposed that the analysed cell lines exhibit two galectin-8 mRNA variants, which encode for the two galectin-8 isoforms detected in immunblot analyses. Coimmunprecipitation studies of the galectin-8 isoforms with different Ras-isoforms revealed that both isoforms preferentially interacted with K-Ras. Therefore, we speculate that galectin-8 proteins might be important in regulating the function of K-Ras and influence K-ras-mediated tumorgenesis of pancreatic cells.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordGalektin-8dc.subject
KeywordRasdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHGalectinsdc.subject.mesh
MeSHGenes, rasdc.subject.mesh
MeSHPancreatic neoplasmsdc.subject.mesh
TitleDie Expression und Lokalisation von Galektin-1, Galektin-3 und Galektin-8 in Pankreaskarzinomzellliniendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2200dc.identifier.doi
PPN663081009dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-76386dc.identifier.urn
GNDBauchspeicheldrüsenkrebsdc.subject.gnd
GNDGalectinedc.subject.gnd
GNDK-rasdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2011-06-14T14:51:18Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 14.111; W: W-H 12.574uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID7638uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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