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Die Expression und Lokalisation von Galektin-1, Galektin-3 und Galektin-8 in Pankreaskarzinomzelllinien

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153 Seiten
Veröffentlichung
2011-06-14
Authors
Porr, Andreea
Dissertation


Faculties
Medizinische Fakultät
Abstract
Galectins comprise a family of animal lectin that exhibits affinity for ß-galactosides. 15 galectins have been identified with various biological functions as neoplasic transformation and metastasis. We investigated the expression pattern and subcellular localisation of galectin-1, -3 and galectin-8 in pancreatic carcinoma cell lines. Most of this cell lines expressed considerable amounts of galectin-1, -3 and -8. RT-PCR analyses exposed that the analysed cell lines exhibit two galectin-8 mRNA variants, which encode for the two galectin-8 isoforms detected in immunblot analyses. Coimmunprecipitation studies of the galectin-8 isoforms with different Ras-isoforms revealed that both isoforms preferentially interacted with K-Ras. Therefore, we speculate that galectin-8 proteins might be important in regulating the function of K-Ras and influence K-ras-mediated tumorgenesis of pancreatic cells.
Date created
2010
Subject headings
[GND]: Bauchspeicheldrüsenkrebs | Galectine | K-ras
[MeSH]: Galectins | Genes, ras | Pancreatic neoplasms
[Free subject headings]: Galektin-8 | Ras
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-2200

Porr, Andreea (2011): Die Expression und Lokalisation von Galektin-1, Galektin-3 und Galektin-8 in Pankreaskarzinomzelllinien. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-2200
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