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AuthorBartelt, Brittadc.contributor.author
Date of accession2016-03-14T11:55:02Zdc.date.accessioned
Available in OPARU since2016-03-14T11:55:02Zdc.date.available
Year of creation2002dc.date.created
AbstractIn this study two different effects of the splice process, aberrant and alternative splicing, on the function of the tumor suppressor protein neurofibromin were investigated. Aberrant splicing was found to be elevated in tumor tissues and may therefore be involved in tumor progression. A previously unknown alternative exon of NF1 was identified which codes for a transmembrane domain thereby conveying a new function to neurofibromin. Looking for mechanisms regulating alternative splicing it was found that intron sequences surrounding alternative exons are highly conserved in evolution and may play an important role in this regulation.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordNF 1dc.subject
MeSHGenes, neurofibromatosis 1dc.subject.mesh
MeSHNeurofibromin 1dc.subject.mesh
TitleSplice processes in the neurofibromatosis type 1 (NF 1) gene: relevance and evolutiondc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-181dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-19815dc.identifier.urn
GNDExondc.subject.gnd
GNDHomologiedc.subject.gnd
GNDIntrondc.subject.gnd
GNDRNS-Spleißendc.subject.gnd
GNDTumorsuppressor-Gendc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2002-09-18T12:42:56Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 7.903 ; W: W-H 7.245uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID1981uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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