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AuthorLebedeva, Elenadc.contributor.author
Date of accession2016-03-15T06:24:34Zdc.date.accessioned
Available in OPARU since2016-03-15T06:24:34Zdc.date.available
Year of creation2009dc.date.created
AbstractThe human genome contains a lot of different types of variations, such as polymorphisms, insertions/deletions and different number of copies of certain fragment. Through different mechanisms some of them may influence individual’s therapy response, occurrence of adverse reaction or cause the susceptibility to certain disease. It’s necessary to carry out the studies that reveal the genetic variations helping to predict the treatment outcome or if an individual will develop certain disease; this is the main step to the personalized medicine that is going to bring the profit to both patients and physicians. Sometimes it’s not easy to evaluate the state of patients, especially when dealing with neurological and psychological disorders. The important parameter in between is an intermediate phenotype that is a surrogate biomarker and is a qualitative measure that allows to make more accurate diagnose and assess the disease progress and monitor response to the treatment. During the work on this thesis there were performed three projects, having similar purpose: to test the effect of polymorphisms involved to the pathway of the intermediate phenotype manifestation.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAlzheimer's diseasedc.subject.mesh
MeSHDepressiondc.subject.mesh
MeSHHaplotypesdc.subject.mesh
MeSHPolymorphism, geneticdc.subject.mesh
TitlePharmacogenetics in neuropsychopharmacology: from clinical associations to intermediate phenotypes of drug responsedc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2038dc.identifier.doi
PPN624620530dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-72543dc.identifier.urn
GNDBiomarkerdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2010-04-16T10:08:28Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.626; W: W-H 12.103uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7254uulm.vtsID
CategoryPublikationenuulm.category


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