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AuthorFlierl, Michaeldc.contributor.author
Date of accession2016-03-15T06:24:28Zdc.date.accessioned
Available in OPARU since2016-03-15T06:24:28Zdc.date.available
Year of creation2008dc.date.created
AbstractThe inflammatory response after severe blunt chest trauma often leads to acute lung injury and acute respiratory distress syndrome which are associated with high mortality rates. Whereas the role of innate immunity in acute lung injury has been broadly investigated, the immune response after blunt chest trauma is still poorly understood. Therefore, the role of complement and neutrophils was determined in bilateral lung injury induced by a single blast wave. The following time-points were investigated posttraumatically: sham, 1, 6, 12, and 24 h. There was a time-dependent systemic activation of complement as determined by CH-50 and presence of C5a-dependent chemotactic plasma activity. Moreover, factor H, a complement regulatory protein, was increased systemically and locally after injury. Anti-C5a treatment immediately after trauma ameliorated these peaks. After an initial systemic leukopenic phase, a marked leukocytosis occurred. The latter was normalized by C5a blockade. In parallel, white blood cell count in bronchioalveolar lavage fluids was increased as a function of time and was significantly decreased by anti-C5a treatment. Trauma-induced lung injury was also associated with dramatic changes in neutrophil function, namely early enhanced chemotaxis and phagocytosis, followed by prolonged functional defects, all of which were ameliorated by anti-C5a treatment. Furthermore, blockade of C5a ameliorated the buildup of the proinflammatory cytokine TNF-alpha, diminished the increase of cytokine-induced neutrophil chemoattractant 1, and altered the levels of the anti-inflammatory cytokine IL-10. These data suggest that blunt chest trauma leads to systemic activation of complement and robust C5a generation, which causes perturbations in defensive functions of neutrophils. Thus, C5a might represent a potential target for therapeutic immunomodulation to prevent immune dysfunctions post-trauma and thereby, perhaps, the progression to acute respiratory distress syndrome.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordStumpfes Thoraxtraumadc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHComplement system proteinsdc.subject.mesh
TitleProtektive Wirkung einer C5A-Blockade nach experimentellem stumpfen Thoraxtraumadc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2003dc.identifier.doi
PPN615944817dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-71608dc.identifier.urn
GNDEntzündungdc.subject.gnd
GNDKomplement C5adc.subject.gnd
GNDNeutrophiler Granulozytdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Citation of original publ.Shock 29 (Jan. 2008), Nr. 1, S. 25 - 31uulm.citationOrigPub
Date of activation2009-12-22T13:04:48Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.522; W: W-H 11.957uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7160uulm.vtsID
CategoryPublikationenuulm.category


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