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AuthorSatzinger, Sebastiandc.contributor.author
Date of accession2016-03-15T06:24:27Zdc.date.accessioned
Available in OPARU since2016-03-15T06:24:27Zdc.date.available
Year of creation2008dc.date.created
AbstractHuntington"s disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by a trias of motor, psychiatric and cognitive dysfunction. The aim of this study was the exploration of the functional neuroanatomy of the working memory (WM) in patients with HD by means of event-related functional magnetic resonance imaging. Using a parametric verbal WM task containing different WM load levels we analysed cerebral function during WM performance in healthy control subjects (n = 16) and HD patients (n = 12). On acount of the applied event-related mechanisms we were able to exclude incorrectly performed trials to control accuracy-related confounders. Voxel-based morphometry was used to control for confounding cortical and subcortical atrophy in the patient group. In comparison with healthy controls, HD patients showed slower and less accurate reactions across all WM load levels. Looking at the functional data, HD patients showed lower activation of a wide network including the left dorso- and ventrolateral prefrontal cortex, the left inferior parietal cortex, the left putamen and the right cerebellum at high WM load levels only. Although voxel-based morphometry revealed significant grey matter differences in the bilateral caudate nucleus and the thalamus, as well as in inferior parietal and lateral prefrontal regions, grey matter reduction in the patient group did not affect the activation differences obtained during WM task performance. In conjunction, these findings point to aberrant cortical functions of HD patients in special working memory related curcuits. Potentially a breakdown of these functional networks is the neurological basis for cognitive deficits and conduct disorders of the HD.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHHuntington diseasedc.subject.mesh
TitleUntersuchung des präfrontalen Kortex und der Arbeitsgedächtnisfunktion bei Patienten mit Morbus Huntingtondc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-2001dc.identifier.doi
PPN615944760dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-71529dc.identifier.urn
GNDArbeitsgedächtnisdc.subject.gnd
GNDFunktionelle NMR-Tomographiedc.subject.gnd
GNDHuntington-Choreadc.subject.gnd
GNDPräfrontaler Cortexdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-12-21T14:17:36Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.480; W: W-H 11.915uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID7152uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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