Dynamics in the cytokine profile of beta-amyloid-specific human T cells
LicenseStandard (Fassung vom 01.10.2008)
Aß1-42-specific antibodies and T cell proliferation point to the existence of a memory response to Aß1-42 in humans. Using ELISPOT, we studied Aß1-42-specific T cells in individuals of various ages and in subjects with Trisomy 21 or Alzheimer’s disease. We show for the first time that Aß1-42 specific Th1-type T cell memory is present in young humans, producing high levels of IFN-gamma and IL-2. With increasing age, the production of IFN-gamma and IL-2 decreases but is not discontinued in healthy subjects and is accompanied by a sharp rise in CD4+ T-cell derived regulatory IL-10 production. In contrast, individuals with Trisomy 21 and with Alzheimer’s disease produce IL-10 only in the absence of any effector cytokine. This signifies a switch from a Th1 effector to an IL-10 mediated regulatory response.
Subject HeadingsAlzheimer-Krankheit [GND]
Immune tolerance [MeSH]
Immunity, cellular [MeSH]