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AuthorBeck, Judithdc.contributor.author
Date of accession2016-03-15T06:24:24Zdc.date.accessioned
Available in OPARU since2016-03-15T06:24:24Zdc.date.available
Year of creation2008dc.date.created
AbstractSeveral studies have shown that admission blood glucose in patients with acute coronary syndromes (ACS) is frequently elevated and associated with increased complications. We sought to investigate the association between increased admission glucose in non-diabetic patients and in patients with type 2 diabetes (T2DM) with a first myocardial infarction (MI) and 28-day as well as 1-year and 3-year-mortality and whether increased blood glucose on admission in non-diabetic patients with first MI is associated with incident type 2 diabetes mellitus (T2DM). We used the MONICA/KORA myocardial registry database in Augsburg, Germany, and included 1.631 patients without and 659 patients with type 2 diabetes (T2DM). Non-diabetic patients with admission glucose above 152 mg/dl (top quartile, Q4) compared to the bottom quartile had an odds ratio (OR) of 2.82 (95 % confidence interval, CI, 1.30 - 6.12) to die within 28 days. Patients with T2DM and admission glucose > 278 mg/dl (Q4) compared to the bottom quartile (< 152 mg/dl) showed a non-significantly increased OR of 1.45 (95 % CI, 0.64 - 3.31) in multivariable logistic regression. One- and three-year-mortality follow-up did not show an significant increased risk to die for patients in the top quartile compared to the bottom quartile of admission glucose, neither for non-diabetic patients, nor for T2DM patients. Compared to non-diabetic MI patients with blood glucose on admission < 111 mg/dl (Q1), non-diabetic patients with levels > 153 mg/dl (Q4) showed an age and sex adjusted relative risk of 2.76; (CI 95 %;1.61 - 4.72) for incident T2DM. Non-diabetic MI patients with increased blood glucose on admission have an increased risk after the acute event to develop manifest T2DM and thus need close monitoring of blood glucose and an oral glucose tolerance test. MI patients without known T2DM but increased admission blood glucose present a high risk group with poor short-term prognosis and thus need aggressive, comprehensive therapy.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
Keyword1-Jahres-Letalitätdc.subject
Keyword28-Tages-Letalitätdc.subject
KeywordAufnahmeblutzuckerwertdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDiabetes mellitus, type 2dc.subject.mesh
TitleBedeutung des Aufnahmeblutzuckerwertes bei Infarktpatienten für die Kurz- und Langzeitletalität sowie die Entwicklung eines Diabetes mellitus Typ 2dc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1983dc.identifier.doi
PPN1648519547dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-71200dc.identifier.urn
GNDDiabetes mellitusdc.subject.gnd
GNDHerzinfarktdc.subject.gnd
GNDInzidenz <Medizin>dc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-11-23T09:31:50Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.465; W: W-H 11.902uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7120uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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