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MRI studies of Gadolinium based contrast agents loaded nanocapsules and iron loaded nanoparticles in chemical and biological environment

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vts_7116_9982.pdf (16.62Mb)
205 Seiten
Veröffentlichung
2009-11-23
Authors
Sharma, Sonu
Dissertation


Faculties
Medizinische Fakultät
Abstract
Molecular imaging by MR is challenging due to the fact that molecular targets are often present in very small numbers. Therefore, the high concentration of contrast agent necessary for detection, severely limits the application of MRI for monitoring molecular processes in vivo. As a result, improved imaging strategies and/or targeted molecular imaging contrast agents with high payload are needed. To achieve the goal of targeted molecular imaging for plaque characterization in future, the objectives of this thesis was to develop and test the potential use of polymeric vehicles (in chemical and biological environment) which can carry high payload of contrast agents to targeted site and serve as potential candidate for targeted molecular imaging. Another aspect was calcium quantification (present in plaque) by MRI using UTE sequence. This in future will help to improve the differentiation between signal losses generated by iron based contrast agents and signal loss due to presence of calcium in plaque.
Date created
2009
Subject headings
[GND]: NMR-Tomographie
[MeSH]: Contrast media | Magnetic resonance imaging | Magnetic resonance imaging, dental
[Free subject headings]: Contrast agents | Inverse miniemulsion | Relaxivity | Ultra short echo-time imaging
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
https://oparu.uni-ulm.de/xmlui/license_v2

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1981

Sharma, Sonu (2009): MRI studies of Gadolinium based contrast agents loaded nanocapsules and iron loaded nanoparticles in chemical and biological environment. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1981
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