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AuthorGraf, Heikodc.contributor.author
Date of accession2016-03-15T06:24:23Zdc.date.accessioned
Available in OPARU since2016-03-15T06:24:23Zdc.date.available
Year of creation2009dc.date.created
AbstractAtomoxetine (ATMX) is a norepinephrine reuptake inhibitor approved for the treatment of ADHD with its core symptoms hyperactivity, inattention and impulsivity. In healthy controls it has been shown that ATMX improves inhibitory control by enhancing prefrontal cortex functioning. However, since inhibitory control will never be perfect, we investigated the drug-effects on the error-monitoring system which is activated when inhibitory control fails. 12 healthy male subjects with hepatic CYP450-2D6-EM status were included. We used a double-blind placebo-controlled within-subject design to examine the effects of 80mg ATMX on neural responses during an fMRI-GoNoGo-Flanker paradigm. Besides neuropsychological tests, self-rating scales and monitoring of cardiovascular functions were applied to control for side effects that might bias interpretation of treatment effects. Pharmacokinetically, we observed an acclerated decline of ATMX serum levels over time. Mean heart rates increased after intake of ATMX. Controlling this cardiovascular effect on MR-based brain perfusion, measurements did not show significant effects. Behaviorally, ATMX led to an increase of trials in which inhibitory control failed. Functionally, ATMX attenuated neural error signals in regions described to error monitoring (IFC/ACC/pre-SMA). Further analyses revealed that this increase in error signals was not dependent on increased error rates, but reflects pure drug effects. Neuropsychological data indexed an increase in phasic alertness. A single-dose of 80mg ATMX resulted in accelerated pharmakokinetics and led to higher heart rates without altering brain perfusion. We observed attenuated neural error signals in relevant brain structures, in combination with increased rate of commission errors. Within the framework of a relationship between performance and arousal (Yerkes-Dodson law) present data are interpreted in terms of a shifted optimal working point of the norepinephrine system in healthy controls.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordError-monitoringdc.subject
KeywordGo/NoGodc.subject
KeywordInhibition controldc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAttention deficit disorder with hyperactivitydc.subject.mesh
TitleModulation kognitiver Funktionen durch die Einnahme einer Einmaldosis des Noradrenalin-Wiederaufnahmehemmers Atomoxetin bei gesunden freiwilligen Probanden: eine randomisierte, placebo-kontrollierte Studie mittels funktioneller Magnetresonanztomographiedc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1979dc.identifier.doi
PPN613930975dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-71126dc.identifier.urn
GNDAtomoxetindc.subject.gnd
GNDAufmerksamkeits-Defizit-Syndromdc.subject.gnd
GNDFunktionelle NMR-Tomographiedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-11-18T10:54:50Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.442; W: W-H 11.880uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7112uulm.vtsID
CategoryPublikationenuulm.category


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