A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Erstveröffentlichung
2019
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Wissenschaftlicher Artikel


Authors
Boettcher, Steffen
Miller, Peter G.
Sharma, Rohan
McConkey, Marie
Leventhal, Matthew
et al.
Institutions
UKU. Klinik für Innere Medizin III
Published in
Science ; 365 (2019), 6453. - S. 599+. - ISSN 0036-8075. - eISSN 1095-9203
Link to publication
https://dx.doi.org/10.1126/science.aax3649
Funding information
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P01CA066996, P50CA206963, R01HL082945]
Howard Hughes Medical Institute
Edward P. Evans Foundation
Leukemia and Lymphoma Society
Adelson Medical Research Foundation
etc.
Keywords
MUTANT P53; CLONAL HEMATOPOIESIS; SOMATIC MUTATIONS; POINT MUTATIONS; GENE ONTOLOGY; K562 CELLS; BCR-ABL; GAIN; CANCER; EXPRESSION
Dewey Decimal Group
DDC 570 / Life sciences
DDC 610 / Medicine & health
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