A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Erstveröffentlichung
2019Authors
Boettcher, Steffen
Miller, Peter G.
Sharma, Rohan
McConkey, Marie
Leventhal, Matthew
Wissenschaftlicher Artikel
Published in
Science ; 365 (2019), 6453. - S. 599+. - ISSN 0036-8075. - eISSN 1095-9203
Link to publication
https://dx.doi.org/10.1126/science.aax3649Institutions
UKU. Klinik für Innere Medizin IIISubject headings
[Free subject headings]: MUTANT P53 | CLONAL HEMATOPOIESIS | SOMATIC MUTATIONS | POINT MUTATIONS | GENE ONTOLOGY | K562 CELLS | BCR-ABL | GAIN | CANCER | EXPRESSION[DDC subject group]: DDC 570 / Life sciences | DDC 610 / Medicine & health