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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Erstveröffentlichung
2019
Authors
Boettcher, Steffen
Miller, Peter G.
Sharma, Rohan
McConkey, Marie
Leventhal, Matthew
et al.
Wissenschaftlicher Artikel


Published in
Science ; 365 (2019), 6453. - S. 599+. - ISSN 0036-8075. - eISSN 1095-9203
Link to publication
https://dx.doi.org/10.1126/science.aax3649
Institutions
UKU. Klinik für Innere Medizin III
Subject headings
[Free subject headings]: MUTANT P53 | CLONAL HEMATOPOIESIS | SOMATIC MUTATIONS | POINT MUTATIONS | GENE ONTOLOGY | K562 CELLS | BCR-ABL | GAIN | CANCER | EXPRESSION
[DDC subject group]: DDC 570 / Life sciences | DDC 610 / Medicine & health

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