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AuthorFeder, Kristindc.contributor.author
Date of accession2019-09-18T14:08:49Zdc.date.accessioned
Available in OPARU since2019-09-18T14:08:49Zdc.date.available
Year of creation2019dc.date.created
Date of first publication2019-09-18dc.date.issued
AbstractAML is the most frequent acute leukemia in adults and is still associated with a high mortality despite intensive chemotherapy and approaches such as allogeneic transplantation. Thus, there is still an urgent need for innovative treatment options. One prerequisite is a better understanding of the biology of AML. The aim of this thesis was to understand differences in expression of LEF1 isoforms between normal and AML stem cells and based on this to explore the possibility to target AML cells by interfering with the binding of LEF1 to β-catenin. A second goal was to identify factors which collaborate with LEF1 to induce AML as LEF1 alone is only able to induce AML after long latency and only in a part of transplanted mice in a murine bone marrow transplantation model.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-on-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordWNTdc.subject
KeywordLEF1dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHWnt signaling pathwaydc.subject.mesh
MeSHWnt proteinsdc.subject.mesh
MeSHLymphoid enhancer-binding factor 1dc.subject.mesh
MeSHLeukemia, myeloid, acutedc.subject.mesh
TitleDissecting the role of lymphoid enhancer factor 1 (LEF1) in acute myeloid leukemiadc.title
Resource typeDissertationdc.type
Date of acceptance2019-08-05dcterms.dateAccepted
RefereeBuske, Christiandc.contributor.referee
RefereeBullinger, Larsdc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-19199dc.identifier.doi
PPN1677775467dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-19256-3dc.identifier.urn
GNDWnt-Proteinedc.subject.gnd
GNDAkute myeloische Leukämiedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Institut für Experimentelle Tumorforschunguulm.affiliationSpecific
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
FundingSFB 1074: Experimentelle Modelle und klinische Translation bei Leukämien / DFG [217328187]uulm.funding
FundingAnalyse der Funktion des "Lymphoid enhancer-binding factor 1" (Lef1) in der Pathogenese der akuten myeloischen Leukämie (A04) SFB 1074 / DFG [217328187]uulm.funding
University Bibliographyjauulm.unibibliographie


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