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AutorZeller, Ankedc.contributor.author
Aufnahmedatum2016-03-15T06:23:33Zdc.date.accessioned
In OPARU verfügbar seit2016-03-15T06:23:33Zdc.date.available
Jahr der Erstellung2010dc.date.created
ZusammenfassungThe aim of the work was the development of bioactive titanium implant coatings, which are able to increase the implant tissue interaction. The incorporation of drugs should additionally advance the wound healing by a controlled release. Different phosphonate, phosphate and sulfonate functionalized polymeric nanoparticles and capsules were synthesized via the miniemulsion technique as coating material. The adhesion forces on metal oxide surfaces were determined by force-distance-measurements with AFM. From the obtained force-distance-measurements it could clearly be seen that the presence of phosphonate groups on the particle surface leads to highly increased adhesion forces between the particles and different metal oxide surfaces. Cell experiments with HeLa cells and MSCs showed that the viability and the differentiation behavior were not affected by the particles. For an effective release of hydrophobic drugs different phosphonate functionalized biodegradable polymeric particles were synthesized in widespread synthesis routes. For the encapsulation of hydrophilic compounds functionalized polymeric capsules with a liquid aqueous core were synthesized in an inverse miniemulsion system.dc.description.abstract
Sprachededc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandard (Fassung vom 01.10.2008)dc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
SchlagwortFunktionalisierte Nanopartikeldc.subject
SchlagwortImplantatbeschichtungdc.subject
SchlagwortKapselndc.subject
SchlagwortPhosphonatgruppendc.subject
DDC-SachgruppeDDC 540 / Chemistry & allied sciencesdc.subject.ddc
LCSHNanoparticlesdc.subject.lcsh
LCSHPhosphonatesdc.subject.lcsh
TitelPhosphonat- und phosphatfunktionalisierte Polymerpartikel und Kapseln für biomedizinische Anwendungen wie Implantatbeschichtungendc.title
RessourcentypDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1871dc.identifier.doi
PPN333744764dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-74228dc.identifier.urn
GNDMiniemulsiondc.subject.gnd
FakultätFakultät für Naturwissenschaftenuulm.affiliationGeneral
Datum der Freischaltung2010-11-16T07:35:08Zuulm.freischaltungVTS
Peer-Reviewneinuulm.peerReview
Signatur DruckexemplarZ: J-H 13.810; W: W-H 12.280uulm.shelfmark
DCMI MedientypTextuulm.typeDCMI
VTS-ID7422uulm.vtsID
KategoriePublikationenuulm.category


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