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AuthorZeller, Ankedc.contributor.author
Date of accession2016-03-15T06:23:33Zdc.date.accessioned
Available in OPARU since2016-03-15T06:23:33Zdc.date.available
Year of creation2010dc.date.created
AbstractThe aim of the work was the development of bioactive titanium implant coatings, which are able to increase the implant tissue interaction. The incorporation of drugs should additionally advance the wound healing by a controlled release. Different phosphonate, phosphate and sulfonate functionalized polymeric nanoparticles and capsules were synthesized via the miniemulsion technique as coating material. The adhesion forces on metal oxide surfaces were determined by force-distance-measurements with AFM. From the obtained force-distance-measurements it could clearly be seen that the presence of phosphonate groups on the particle surface leads to highly increased adhesion forces between the particles and different metal oxide surfaces. Cell experiments with HeLa cells and MSCs showed that the viability and the differentiation behavior were not affected by the particles. For an effective release of hydrophobic drugs different phosphonate functionalized biodegradable polymeric particles were synthesized in widespread synthesis routes. For the encapsulation of hydrophilic compounds functionalized polymeric capsules with a liquid aqueous core were synthesized in an inverse miniemulsion system.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordFunktionalisierte Nanopartikeldc.subject
KeywordImplantatbeschichtungdc.subject
KeywordKapselndc.subject
KeywordPhosphonatgruppendc.subject
Dewey Decimal GroupDDC 540 / Chemistry & allied sciencesdc.subject.ddc
LCSHNanoparticlesdc.subject.lcsh
LCSHPhosphonatesdc.subject.lcsh
TitlePhosphonat- und phosphatfunktionalisierte Polymerpartikel und Kapseln für biomedizinische Anwendungen wie Implantatbeschichtungendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1871dc.identifier.doi
PPN640751571dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-74228dc.identifier.urn
GNDMiniemulsiondc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2010-11-16T07:35:08Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.810; W: W-H 12.280uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID7422uulm.vtsID
CategoryPublikationenuulm.category


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