Modulation of growth factor function by additional extracellular signals in CNS neurones and glia

Abstract

The development of the CNS involves complex processes and mechanisms requiring a multitude of epigentic factors. Even single epigenetic factors themselves often have diverse effects on the same cells. FGF-2, for example, is a potent mitogen and differentiation factor for astroglia during both the development and regeneration of the CNS, while the neurotrophin BDNF can induce synaptic activation, growth of dendrites, and promote survival of neurons. The mechanisms by which these factors can exert multiple effects are presently not well defined. Therefore, it is hypothesised here that additional factors are required to serve a modulating role. Two systems from the nervous system are studied: (i) the effects of additional signals, specifically cAMP, on the function, and signalling of FGF-2 in glia cells, and (ii) the effects of similar factors on neurotrophin-induced survival in CNS neurons.