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Modulation of growth factor function by additional extracellular signals in CNS neurones and glia

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vts_941.pdf (1006.Kb)
109 Seiten
Veröffentlichung
2002-01-13
Authors
Bayatti, Nadhim
Dissertation


Faculties
Medizinische Fakultät
Abstract
The development of the CNS involves complex processes and mechanisms requiring a multitude of epigentic factors. Even single epigenetic factors themselves often have diverse effects on the same cells. FGF-2, for example, is a potent mitogen and differentiation factor for astroglia during both the development and regeneration of the CNS, while the neurotrophin BDNF can induce synaptic activation, growth of dendrites, and promote survival of neurons. The mechanisms by which these factors can exert multiple effects are presently not well defined. Therefore, it is hypothesised here that additional factors are required to serve a modulating role. Two systems from the nervous system are studied: (i) the effects of additional signals, specifically cAMP, on the function, and signalling of FGF-2 in glia cells, and (ii) the effects of similar factors on neurotrophin-induced survival in CNS neurons.
Date created
2001
Subject headings
[GND]: cAMP-bindendes Protein | Glia | Neurotropher Faktor | Zelldifferenzierung
[MeSH]: Central nervous system. Physiology | Neurons
[Free subject headings]: cAMP | FGF-2
License
Standard (Fassung vom 03.05.2003)
https://oparu.uni-ulm.de/xmlui/license_v1

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-154

Bayatti, Nadhim (2002): Modulation of growth factor function by additional extracellular signals in CNS neurones and glia. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-154
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