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AuthorKuhn, Eva-Mariadc.contributor.author
Date of accession2016-03-14T15:23:21Zdc.date.accessioned
Available in OPARU since2016-03-14T15:23:21Zdc.date.available
Year of creation2009dc.date.created
AbstractMembers of the tetraspanin protein family are modulators of several fundamental cellular processes like proliferation, adhesion and migration in various cell types. These cellular processes are deregulated in microvascular retinal endothelial cells in diabetic retinopathy (DR). However, expression and function of these proteins have not been studied in microvascular endothelial cells despite their (patho-)physiological importance. Western blotting, FACS or RT-PCR analyses confirmed that CD9 and other tetraspanins are expressed in immortalized microvasular endothelial cells of the bovine retina. In addition, association of CD9 with metalloproteases, protein kinase C (PKC) and integrins have been described for several cell types and these proteins might play a role in the development of DR. To elucidate the significance of these interactions for retinal diseases, these putative protein complexes were studied in iBREC.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordMicrovascular endothelial cellsdc.subject
KeywordTetraspanindc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHADAM proteinsdc.subject.mesh
MeSHDiabetic retinopathydc.subject.mesh
MeSHIntegrindc.subject.mesh
MeSHProstheses and implantsdc.subject.mesh
TitleCharakterisierung von Proteinkomplexen des Tetraspanins CD9 mit Bedeutung für die Migration mikrovaskulärer retinaler Endothelzellendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1647dc.identifier.doi
PPN614144353dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-69472dc.identifier.urn
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-08-09T22:00:56Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.416; W: W-H 11.855uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID6947uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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