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AutorLiao, Yunxiangdc.contributor.author
Aufnahmedatum2016-03-14T15:23:16Zdc.date.accessioned
In OPARU verfügbar seit2016-03-14T15:23:16Zdc.date.available
Jahr der Erstellung2009dc.date.created
ZusammenfassungBrain voltage-gated sodium channels are complexes of a pore-forming alpha subunit and auxiliary beta1 and beta2 subunits with modulation effects. They play critical roles in initiation and generation of action potentials. Gene defects in these channels are identified associating with idiopathic epilepsy. Four sodium channel mutations related to idiopathic epilepsies and the modifications of sodium channel gating by beta subunits were functionally characterized. Electrophysiological, immunocytochemical investigations in the primary cultured rat cortical neurons established stable experimental process for the further studies in cultured neurons and demonstrated various classes of cortical neuron.dc.description.abstract
Spracheendc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandard (ohne Print-On-Demand)dc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
SchlagwortIdiopathic epilepsiesdc.subject
DDC-SachgruppeDDC 610 / Medicine & healthdc.subject.ddc
MeSHEpilepsydc.subject.mesh
MeSHKcnq2 protein, mousedc.subject.mesh
MeSHSodium channelsdc.subject.mesh
TitelFunctional characterization of voltage-gated sodium channels associated with human idiopathic epilepsiesdc.title
RessourcentypDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1629dc.identifier.doi
PPN30857091Xdc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-69002dc.identifier.urn
FakultätMedizinische Fakultätuulm.affiliationGeneral
Datum der Freischaltung2009-07-14T12:22:29Zuulm.freischaltungVTS
Peer-Reviewneinuulm.peerReview
Signatur DruckexemplarZ: J-H 13.324; W: W-H 11.761uulm.shelfmark
DCMI MedientypTextuulm.typeDCMI
VTS-ID6900uulm.vtsID
KategoriePublikationenuulm.category


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