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AuthorLiao, Yunxiangdc.contributor.author
Date of accession2016-03-14T15:23:16Zdc.date.accessioned
Available in OPARU since2016-03-14T15:23:16Zdc.date.available
Year of creation2009dc.date.created
AbstractBrain voltage-gated sodium channels are complexes of a pore-forming alpha subunit and auxiliary beta1 and beta2 subunits with modulation effects. They play critical roles in initiation and generation of action potentials. Gene defects in these channels are identified associating with idiopathic epilepsy. Four sodium channel mutations related to idiopathic epilepsies and the modifications of sodium channel gating by beta subunits were functionally characterized. Electrophysiological, immunocytochemical investigations in the primary cultured rat cortical neurons established stable experimental process for the further studies in cultured neurons and demonstrated various classes of cortical neuron.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-On-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordIdiopathic epilepsiesdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHEpilepsydc.subject.mesh
MeSHKcnq2 protein, mousedc.subject.mesh
MeSHSodium channelsdc.subject.mesh
TitleFunctional characterization of voltage-gated sodium channels associated with human idiopathic epilepsiesdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1629dc.identifier.doi
PPN30857091Xdc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-69002dc.identifier.urn
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-07-14T12:22:29Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.324; W: W-H 11.761uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6900uulm.vtsID
CategoryPublikationenuulm.category


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