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AuthorSchmieder, Michaeldc.contributor.author
Date of accession2016-03-14T15:23:15Zdc.date.accessioned
Available in OPARU since2016-03-14T15:23:15Zdc.date.available
Year of creation2008dc.date.created
AbstractIn spite of multiple efforts a reliable risk-classification of human gastrointestinal stromal tumours could not be established in the past. So it was the aim of this study to investigate the predictive value of the immunohistochemical expression of several proteins and other factors in these malignancies. Focus was set on EGFR, P53 and P16. First, the adverse effect of big size and high mitotic rate could be shown significantly. For the parameter EGFR by contrast, no predictive value could be found. However, significantly could be shown the unfavorable effect of the expression of P53 in disease-free- as well as in disease-specific-survival. Concerning P16, a differentiation of the subgroup "high-risk" after consensus classification could be established. Patients with such high-risk-tumours and immunohistochemical expression of P16 had a much worse outcome in disease-free- and disease-specific-survival respectively. So P16 might be used as a predictor for "very-high-risk"-GIST.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
Keywordp16dc.subject
KeywordProteinexpressiondc.subject
KeywordStromatumordc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHGastrointestinal neoplasmsdc.subject.mesh
MeSHGastrointestinal stromal tumorsdc.subject.mesh
MeSHPrognosisdc.subject.mesh
MeSHReceptor, epidermal growth factordc.subject.mesh
TitleExpression und prognostische Bedeutung verschiedener Proteine bei gastrointestinalen Stromatumorendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1625dc.identifier.doi
PPN164815896Xdc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-68930dc.identifier.urn
GNDEpidermaler Wachstumsfaktor-Rezeptordc.subject.gnd
GNDProtein p53dc.subject.gnd
GNDRisikodc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-07-02T11:06:10Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.331; W: W-H 11.767uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6893uulm.vtsID
CategoryPublikationenuulm.category


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