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Expression und prognostische Bedeutung verschiedener Proteine bei gastrointestinalen Stromatumoren

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vts_6893_9576.pdf (2.155Mb)
89 Seiten
Veröffentlichung
2009-07-02
Authors
Schmieder, Michael
Dissertation


Faculties
Medizinische Fakultät
Abstract
In spite of multiple efforts a reliable risk-classification of human gastrointestinal stromal tumours could not be established in the past. So it was the aim of this study to investigate the predictive value of the immunohistochemical expression of several proteins and other factors in these malignancies. Focus was set on EGFR, P53 and P16. First, the adverse effect of big size and high mitotic rate could be shown significantly. For the parameter EGFR by contrast, no predictive value could be found. However, significantly could be shown the unfavorable effect of the expression of P53 in disease-free- as well as in disease-specific-survival. Concerning P16, a differentiation of the subgroup "high-risk" after consensus classification could be established. Patients with such high-risk-tumours and immunohistochemical expression of P16 had a much worse outcome in disease-free- and disease-specific-survival respectively. So P16 might be used as a predictor for "very-high-risk"-GIST.
Date created
2008
Subject headings
[GND]: Epidermaler Wachstumsfaktor-Rezeptor | Protein p53 | Risiko
[MeSH]: Gastrointestinal neoplasms | Gastrointestinal stromal tumors | Prognosis | Receptor, epidermal growth factor
[Free subject headings]: p16 | Proteinexpression | Stromatumor
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1625

Schmieder, Michael (2009): Expression und prognostische Bedeutung verschiedener Proteine bei gastrointestinalen Stromatumoren. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1625
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