Expression und prognostische Bedeutung verschiedener Proteine bei gastrointestinalen Stromatumoren

Abstract

In spite of multiple efforts a reliable risk-classification of human gastrointestinal stromal tumours could not be established in the past. So it was the aim of this study to investigate the predictive value of the immunohistochemical expression of several proteins and other factors in these malignancies. Focus was set on EGFR, P53 and P16. First, the adverse effect of big size and high mitotic rate could be shown significantly. For the parameter EGFR by contrast, no predictive value could be found. However, significantly could be shown the unfavorable effect of the expression of P53 in disease-free- as well as in disease-specific-survival. Concerning P16, a differentiation of the subgroup "high-risk" after consensus classification could be established. Patients with such high-risk-tumours and immunohistochemical expression of P16 had a much worse outcome in disease-free- and disease-specific-survival respectively. So P16 might be used as a predictor for "very-high-risk"-GIST.