Zur Kurzanzeige

AutorFinsterbusch, Frankdc.contributor.author
Aufnahmedatum2016-03-14T15:23:04Zdc.date.accessioned
In OPARU verfügbar seit2016-03-14T15:23:04Zdc.date.available
Jahr der Erstellung2007dc.date.created
ZusammenfassungThe ability of 11C-Choline and multimodality fusion imaging with integrated PET and contrast-enhanced CT was investigatet to delineate prostate carcinoma within the prostate and differentiate cancer tissue from normal prostate, benign prostate hyperplasia, and focal chronic prostatitis. RESULTS: The SUV of 11C-Choline in PCa tissue was 3.5 +/- 1.3 (mean +/- SD) and significantly higher than that in prostate tissue with benign histopathologic lesions (2.0 +/- 0.6; p<0.001 benign histopathology vs. cancer). A threshold SUV of 2.65 yielded an area under the reciever-operating-characteristic (ROC) curve of 0.89 +/- 0.01 for correctly locating PCa. CONCLUSION: 11C-Choline PET/CT can accurately detect and locate major areas with PCa and differentiate segments with PCa from those with benign hyperplasia, chronic prostatitis, or normal prostate tissue. Within patients with antihormonal treatment 11C-Choline PET/CT diagnostics failed to accurately detect PCa areas within the prostate and could not differentiate between benign and malignant tissue. The maximal tumoral 11C-Choline uptake is related to pT stage.dc.description.abstract
Sprachededc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandard (Fassung vom 01.10.2008)dc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
SchlagwortPET/CTdc.subject
DDC-SachgruppeDDC 610 / Medicine & healthdc.subject.ddc
MeSHProstatic neoplasmsdc.subject.mesh
TitelWertigkeit der 11 C-Cholin-PET/CT in der Primärdiagnostik des Prostatakarzinomsdc.title
RessourcentypDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1581dc.identifier.doi
PPN304771325dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-67420dc.identifier.urn
GNDPositronen-Emissions-Tomographiedc.subject.gnd
GNDProstatakrebsdc.subject.gnd
FakultätMedizinische Fakultätuulm.affiliationGeneral
Datum der Freischaltung2009-03-06T08:26:12Zuulm.freischaltungVTS
Peer-Reviewneinuulm.peerReview
Signatur DruckexemplarZ: J-H 13.183; W: W-H 11.628uulm.shelfmark
DCMI MedientypTextuulm.typeDCMI
VTS-ID6742uulm.vtsID
KategoriePublikationenuulm.category


Dateien zu dieser Ressource

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige