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AuthorLichtenegger, Felixdc.contributor.author
Date of accession2016-03-14T15:23:02Zdc.date.accessioned
Available in OPARU since2016-03-14T15:23:02Zdc.date.available
Year of creation2008dc.date.created
AbstractAdministration of autoantigens under conditions that induce type 2 immunity frequently leads to protection from T cell-mediated autoimmune diseases. Such treatments, however, are inherently linked to the induction of IgG1 Abs and to the risk of triggering anaphylactic reactions. We studied the therapeutic benefit vs. risk of immune deviation in experimental allergic encephalomyelitis of SJL mice induced by MP4, a myelin basic protein-proteolipid protein (PLP) fusion protein. MP4 administration in IFA induced type 2 T cell immunity, IgG1 Abs, and experimental allergic encephalomyelitis protection, and all three were enhanced by repeat injections. Despite high Ab titers, anaphylactic side reactions were not observed when MP4 was repeatedly injected in IFA or as soluble Ag s.c. In contrast, lethal anaphylaxis was seen after s.c. injection of soluble PLP:139 - 151 peptide, but not when the peptide was reinjected in IFA. Therefore, the Ab response accompanying the immune therapy constituted an anaphylactic risk factor only when the autoantigen was not retained in an adjuvant and when it was small enough to be readily disseminated within the body. Taken together, our data show that treatment regimens can be designed to boost the protective type 2 T cell response while avoiding the risk of Ab-mediated allergic side effects.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
ID of original publ.doi:10.4049/jimmunol.178.8.4749dc.relation.uri
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordExperimentelle autoimmune Enzephalomyelitisdc.subject
KeywordImmundeviationdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
TitleDissociation of the protection from experimental autoimmune enzephalomyelitis and the allergic side reactions in tolerization with the neuroantigen MP4dc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1576dc.identifier.doi
PPN1651365741dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-67371dc.identifier.urn
GNDAllergiedc.subject.gnd
GNDAnaphylaxiedc.subject.gnd
GNDAutoimmunitätdc.subject.gnd
GNDEncephalomyelitisdc.subject.gnd
GNDImmunologiedc.subject.gnd
GNDMultiple Sklerosedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Citation of original publ.Lichtenegger, F. S.; Kuerten, S.; Faas, S.; Boehm, B. O.; Tary-Lehmann, M. and Lehmann, P. V.: Dissociation of EAE protective effect and allergic side reactions in tolerization with neuroantigen. In: Journal of immunology 178 (2007 Apr 15), 8, S. 4749-56uulm.citationOrigPub
Date of activation2009-03-05T16:01:42Zuulm.freischaltungVTS
Peer reviewjauulm.peerReview
Shelfmark print versionZ: J-H 13.186; W: W-H 11.631uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6737uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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