Detektion von Phäochromozytomen und rekurrenten medullären Schilddrüsenkarzinomen mit F18 DOPA PET/CT
Dissertation
Faculties
Medizinische FakultätAbstract
Evaluating [18F]dihydroxyphenylalanine (DOPA) in patients with clinical suspicion for a primary or recurrent pheochromocytoma (pheo) by means of whole body PET/CT. In pheos PET/CT detects more lesions with a higher certainty with regard to PET or CT alone. The metabolic probe fluorine-18-dihydroxyphenylalanine (F-18-DOPA) was also evaluated in MTC patients by means of whole body PET/CT to localize resectable tumor lesions. The lesion classification relied mainly on pathological 18F-DOPA uptake, whereas the certainty of lesion location was markedly increased by the integrated PET/CT approach. Integrated F-18-DOPA-PET/CT is a promising diagnostic approach to identify residual disease in MTC patients, potentially increasing the rate of surgical cure.
DOPA PET/CT is therefore a valuable diagnostic tool especially in management of MEN patients, since it detects pheos as well as recurrent MTC.
Date created
2008
Subject headings
[GND]: Calcitonin | MTC | Phäochromozytom[MeSH]: Pheochromocytoma | Thyroid neoplasms
[Free subject headings]: F18 DOPA | MEN 2 | PET/CT
[DDC subject group]: DDC 610 / Medicine & health
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1569
Zeich, Katrin (2009): Detektion von Phäochromozytomen und rekurrenten medullären Schilddrüsenkarzinomen mit F18 DOPA PET/CT. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1569
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